检验医学与临床2017，Vol.14Issue(2)：187-189,3.DOI:10.3969/j.issn.1672-9455.2017.02.013
血清γ-谷氨酰基转移酶总活性在冠心病严重程度评估中的应用
The application of the serum total GGT activity in detection of the severity of coronary heart disease
摘要
Abstract
Objective To retrospectively analyze the relationship between the severity of coronary heart disease and serum total GGT activity .Methods The subjects were divided into unstable angina pectoris group (UA ,n=465) ,stable angina pectoris group (SAP ,n=665)and the control group (angiography negative ,n=126) .The level of serum total GGT activity was measured by enzy‐mic method ,the level of serum homocysteine (Hcy) was measured by circulating enzymic method ,the level of serum hs‐CRP was detected by immunoturbidimetry and the levels of fibrinogen (FG) were also detected .The differences between the three groups were compared .All patients were followed up for one year ,subsequent cardiovascular events (including myocardial infarction , death) were recorded ,and the relationship between the total GGT activity and cardiac events was analyzed .Results The levels of total GGT activity [(43 .74 ± 18 .78)U/L] ,Hcy[(23 .74 ± 8 .78)mol/L] in UA group were significantly higher than SAP group [(30 .13 ± 11 .43)U/L ,(15 .13 ± 11 .43)mol/L ,P<0 .05] .There was no significant difference in FG and hs‐CRP between the two groups (P> 0 .05) .The levels of total GGT activity ,Hcy ,FG ,hs‐CRP in SAP group were significantly higher than the control group(P<0 .05) .The rate of subsequent cardiovascular events was higher in the patients with elevated level of total GGT activity (>60 .56 U/L) .Conclusion Combined detection of GGT ,Hcy ,FG ,hs‐CRP can better understand the degree of coronary heart dis‐ease ,especially the total serum GGT activity and Hcy .Total GGT activity is closely related to the degree of coronary heart disease , and the follow‐up shows that the incidence of cardiac events is higher in the patients with high GGT activity .关键词
γ-谷氨酰基转移酶/不稳定性心绞痛/稳定性心绞痛Key words
GGT/unstable angina pectoris/stable angina pectoris引用本文复制引用
林炜炜,徐晓萍,彭凤,李敏..血清γ-谷氨酰基转移酶总活性在冠心病严重程度评估中的应用[J].检验医学与临床,2017,14(2):187-189,3.基金项目
上海市卫生局科研资助项目（20134460）。 （）
