检验医学与临床2017，Vol.14Issue(2)：198-200,203,4.DOI:10.3969/j.issn.1672-9455.2017.02.016
原发性胆汁性肝硬化患者Ig G型自身抗体检测的临床价值
The clinical value of IgG autoantibodies detection in patients with primary biliary cirrhosis
摘要
Abstract
Objective To analyze the spectrum of autoimmune liver disease in patients with primary biliary cirrhosis (PBC) and to investigate the clinical significance of PBC in the diagnosis and clinical application .Methods Totally 67 cases of PBC and 70 ca‐ses of disease control were selected as the research subjects .Detection of anti nuclear antibodies and indirect immunofluorescence detection of anti nuclear antibodies ,using SPSS17 .0 statistical software for analysis and processing .Results The positive detection rate of PBC patients was mainly AMA‐M2 antibody ,Sp100 antibody and gp210 antibody ,and ANA fluorescent nuclear type was mainly nuclear and cytoplasmic particle type .The positive rates of AMA‐M2 ,anti Sp100 antibody and anti gp210 antibody in PBC patients were significantly higher than those in the control group (χ2 =37 .228 ,5 .492 and 16 .292 ,P<0 .01) .In comparison with the control group ,there was no significant difference in the positive rate of LKM 1 antibody ,LC1 antibody and SLA antibody (P>0 .05) .Conclusion Antibody spectrum of autoimmune liver disease ,especially the AMA‐M2 positive serum is one of the important indicators in the diagnosis of PBC ,in addition ,Sp100 antibody ,gp210 antibody is also the characteristic of PBC diagnosis antibody , which has an important role in the diagnosis of AMA‐M2 negative PBC .关键词
原发性胆汁性肝硬化/自身抗体/IgG型抗体Key words
primary biliary cirrhosis/autoantibodies/IgG antibody引用本文复制引用
董玉琳,张胜,彭传梅,尧颖..原发性胆汁性肝硬化患者Ig G型自身抗体检测的临床价值[J].检验医学与临床,2017,14(2):198-200,203,4.基金项目
云南省科技厅-昆明医科大学联合专项项目（2015FB086）；昆明医科大学研究生创新基金资助项目（2016S43）。 （）
