检验医学与临床2017，Vol.14Issue(4)：472-475,4.DOI:10.3969/j.issn.1672-9455.2017.04.007
盐酸右美托咪定联合肢体远隔缺血预处理在胸腔镜肺切除术中的疗效评价
Evaluation on the effect of Dexmedetomidine hydrochloride combined with limb remote ischemic preconditioning in patients with thoracoscopic lung resection
摘要
Abstract
Objective To study the effect of Dexmedetomidine hydrochloride combined with limb remote ischemic precondition ‐ing in patients with thoracoscopic lung resection .Methods A total of 80 patients with thoracoscopic lung resection were recruited in this study from November 2015 to September 2016 ,and were divided into control group and observation group by digital method , 40 cases in each group .Dexmedetomidine hydrochloride combined with limb remote ischemic were used to protect the patients in the observation group after operating .Only limb remote ischemic protect the patients in the control group .Before operation(T1) ,30 min after one‐lung ventilation(T2) ,operation over(T3) ,after operation 6 h(T4) ,after operation 24 h(T5) ,calculated P(A‐a) DO2 and OI value ,detected serum Tumor necrosis factor (TNF)‐alpha ,interleukin(IL ) 6 ,plasma superoxide dismutase(SOD) activity ,ma‐londialdehyde(MDA) ,and observe the complications in the two groups .Results P(A‐a)DO2 at T3 ,T4 in the observation group in‐creased significantly lower than that in the control group (P< 0 .05) .In the control group ,compared with that of T 1 ,P(A‐a)DO2 at T2 ,T3 ,T4 increased gradually(P< 0 .05) ,there were no differences at different time in the observation group (P> 0 .05) .OI at T4 in the observation group declined significantly lower than that in the control group (P< 0 .05) .In the control group ,compared with that of T1 ,OI at T2 ,T3 ,T4 ,T5 declined gradually(P< 0 .05) ,there were no differences at different time in the observation group (P> 0 .05) .Compared with those at T1 ,serum TNF‐alpha ,IL‐6 levels were significant lower at other times in the two groups (P<0 .05) .Serum MDA at T3 ,T4 declined and SOD level increased in the observation group obviously lower than those in the control group(P< 0 .05) .In the control group ,the SOD level significantly decreased ,MDA level significantly increased at T3 ,T4 compared with those at T1(P< 0 .05) .In observation group ,SOD ,MDA levels had no significant differences among each time point (P >0 .05) .The complications in the observation group and control group were 7 .5% and 12 .5% respectively ,the difference wasn′t sig‐nificant(P> 0 .05) .Conclusion Dexmedetomidine hydrochloride combined with limb remote ischemic preconditioning could inhibit the effect of inflammatory cells ,reduce the consumption of SOD ,reduce ischemia reperfusion injury of lung ,also have less influence on pulmonary ventilation and oxygenation function .关键词
盐酸右美托咪定/上臂缺血预处理/肺损伤Key words
Dexmedetomidine hydrochloride/limb remote ischemic preconditioning/lung injury引用本文复制引用
谢娟华,黄宏艳,张亚军,刘枧辉,林丽..盐酸右美托咪定联合肢体远隔缺血预处理在胸腔镜肺切除术中的疗效评价[J].检验医学与临床,2017,14(4):472-475,4.基金项目
深圳市龙华新区科技计划项目（1030101）。 （）
