检验医学与临床2017，Vol.14Issue(4)：479-481,3.DOI:10.3969/j.issn.1672-9455.2017.04.009
依达拉奉对颅内肿瘤γ-刀术后脑水肿的治疗作用及对血清肿瘤坏死因子-α水平的影响分析
Analysis of therapeutic effects and serum TNF-α levels effects of edaravone on cerebral edema after gamma knife treatment of intracranial tumor
狄淬砺 1赵亚群 1王永 1梁晋川1
作者信息
- 1. 中国人民解放军第三零九医院神经外科，北京 100091
- 折叠
摘要
Abstract
Objective To investigate the therapeutic effects and serum TNF‐α levels effects of edaravone on cerebral edema after gamma knife treatment of intracranial tumor .Methods Used a prospective study method ,98 cases of No .309 hospital of PLA for diagnosis and treatment of intracranial tumor gamma‐knife radiosurgery of brain edema patients were selected from February 2014 to January 2016 ,accorded to admission order were equally divided into observation group and control group ,each group were 49 ca‐ses ,the control group were given the ranitidine hydrochloride Buflomedil injection in the treatment ,the observation group were giv‐en the edaravone injection in the treatment ,two groups were given conventional treatment ,the treatment observation times were 14d .Results The total effective rate of the observation group was 98 .0% ,and the control group was 79 .6% .The total effective rate of the observation group was significantly higher than that of the control group (P< 0 .05) .The serum TNF‐α levels after the treatment were(113 .92 ± 23 .81) and(289 .49 ± 42 .10)ng/L that were significantly lower than before treatment of (882 .94 ± 30 .81) and(879 .13 ± 41 .92)ng/L(P< 0 .05) ,the observation group was significantly lower than the control group (P< 0 .05) .The area of cerebral edema in the observation group and control group after treatment were significantly reduced (P< 0 .05) ,and the observation group was significantly less than the control group after treatment (P < 0 .05) .The GCS scores in the observation group and the control group before treatment were(7 .23 ± 0 .45)points and(7 .19 ± 0 .67)points ,after treatment were(13 .87 ± 1 .11) points and (10 .48 ± 1 .49)points that were significantly higher than that before treatment (P< 0 .05) ,while the observation group was signifi‐cantly higher than that of the control group (P < 0 .05) .Conclusion The application of edaravone in the treatment of intracranial tumor gamma knife radiosurgery of brain edema can effectively reduce inflammation ,alleviate brain edema and improve the GCS score ,it′s conducive to the improvement of comprehensive effect and has very good application values .关键词
脑水肿/依达拉奉/肿瘤坏死因子-α/脑水肿面积/GCS 评分Key words
cerebral edema/edaravone/TNF-α/cerebral edema area/GCS score引用本文复制引用
狄淬砺,赵亚群,王永,梁晋川..依达拉奉对颅内肿瘤γ-刀术后脑水肿的治疗作用及对血清肿瘤坏死因子-α水平的影响分析[J].检验医学与临床,2017,14(4):479-481,3.
