检验医学与临床2017，Vol.14Issue(4)：497-499,3.DOI:10.3969/j.issn.1672-9455.2017.04.016
树突状细胞诱导的杀伤细胞治疗非霍奇金淋巴瘤患者的应用价值
The application of DC-CIK in the treatment of non Hodgkin′s lymphoma
李兴 1马丽娜 2彭大为1
作者信息
- 1. 中南大学湘雅医学院附属海口医院/海南省海口市人民医院 肿瘤化疗科 570208
- 2. 中南大学湘雅医学院附属海口医院/海南省海口市人民医院 神经内科 570208
- 折叠
摘要
Abstract
Objective To explore the effect of DC‐CIK in the treatment of non Hodgkin lymphoma .Methods 84 cases of non Hodgkin′s lymphoma in Haikou People′s Hospital ,Central South University Xiangya Medical College Hospital from January 2011 to December 2014 were selected as the research object .The patients were randomly divided into observation group and control group by digital table method .The observation group was treated with DC‐CIK ,and the control group was treated with CIK .Will Ag‐DC centrifugal washing after the sensitization of CIK cells ,with 100 mL saline ,25 mL blood albumin rhIL‐2 and 200 000 unit weight suspension cells ,2 hours loss to the patient′s body back ,back to lose before giving intramuscular injection in patients with 25 mg promethazine hydrochloride .The therapeutic effect of the two groups was observed .Results Cell proliferation rate in observation group were significantly higher than the control group .And in the training on the sixth day ,number of cells in observation group were significantly greater than the control group .Cellular immune phenotypic differences of two groups of patients were compared , and the results showed that with the increase of incubation time ,DC ,CIK cells to CD3 + CD8 + and CD3 + CD56 + double the propor‐tion of positive cells were significantly higher than that of the same condition of CIK cells ,and DC‐CIK cells secrete factors levels were significantly higher than that of the same condition of CIK cells ,and the above differences are significant statistical difference (P< 0 .05) .Conclusion DC‐CIK cells have a very wide application prospect in the application of non Hodgkin lymphoma ,which is worthy of clinical application .关键词
树突状细胞诱导的杀伤细胞/非霍奇金淋巴瘤/免疫/细胞Key words
DC-CIK/non Hodgkin lymphoma/immune/cell引用本文复制引用
李兴,马丽娜,彭大为..树突状细胞诱导的杀伤细胞治疗非霍奇金淋巴瘤患者的应用价值[J].检验医学与临床,2017,14(4):497-499,3.
