山东医药2017，Vol.57Issue(3)：1-4,4.DOI:10.3969/j.issn.1002-266X.2017.03.001
无锡地区孕中期孕妇血清AFP、freeβ-HCG、uE3中位数标化及其应用
Standardization and application of median equation of AFP,free β-HCG and uE3 in the second trimester of pregnant women in Wuxi
摘要
Abstract
Objective To detect the median equation of maternal serum markers including free β-human chorionic gonadotrophin (free β-hCG),alpha-fetoprotein (AFP),and unconjugated estriol (uE3)in the second trimester of single-birth pregnant women in Wuxi and to establish the regional parameters for triple screening model based on revised gestation age and weight.We also evaluated the efficacy of this method in risk assessment of trisomy 21 syndrome (DS),trisomy 18 syndrome (ES)and neural tube defect (NTD).Methods The levels of AFP,free β-hCG and μE3 were detected in 8 783 single-birth pregnant women (15-20 +6 gestational weeks)in Wuxi.The median of serum AFP,free β-hCG and uE3 levels were analyzed by Life Cycle 4.0 software.And then we got the new median after adjusting the standard of gestational age and body mass.ES and NTD risk assessment was performed by using the standardized median,and the application efficien-cy of the median of the serum indexes before and after the standardization was compared by taking the results of the amniotic fluid karyotype analysis and the postnatal outcome as the standard.Results The median of free β-hCG in the second tri-mester of normal pregnant women in Wuxi was significantly higher as compared with the un-standardized median from Cau-casia women(all P <0.01).After revising gestational age and weight,the false positive rate (4.59%)for DS in standard-ized median equation was higher than that in the software built-in (3.97%).The screening efficiency for DS,ES and NTD in standardized median equation was improved as compared with that in the software built-in.Meanwhile,the total detection rate (10 /12)for DS,ES and NTD in standardized median equation was higher than that in the software built-in (8 /12). Compared with the values of mMoMin serum markers of the software built-in,the values of mMoMin the standardized ones were higher in AFP,but lower in free β-hCG and μE3 (all P <0.01).Conclusions The median of AFP,free β-HCG and uE3 based on standardized gestation age and weight is established,which is different from the LifeCycle 4.0 median. The standardized median equations may help to improve the screening efficiency.关键词
妊娠中期/产前筛查/甲胎蛋白/β-人绒毛膜促性腺激素/雌三醇/标准化/21 三体综合征/18 三体综合征/神经管缺陷/无锡地区Key words
second trimester of pregnancy/prenatal screening/alpha-fetoprotein/β-human chorionic gonadotropin/estriol/standardization/trisomy 21 syndrome/trisomy 18 syndrome/neural tube defects/Wuxi分类
医药卫生引用本文复制引用
杨岚,石皓,赵丽,陶荷花,刘俊,王俊..无锡地区孕中期孕妇血清AFP、freeβ-HCG、uE3中位数标化及其应用[J].山东医药,2017,57(3):1-4,4.基金项目
江苏省妇幼保健重点资助项目（F201315）；无锡市医管中心面上项目（YGZXM1510）；无锡市科技发展基金项目（CSE31N1511）。 （）
