世界中医药2016，Vol.11Issue(12)：2630-2633,4.DOI:10.3969/j.issn.1673-7202.2016.12.028
银杏叶提取物对阿尔茨海默病患者认知功能的效果及其对相关因子的影响
Effect of Ginkgo biloba extract on Cognitive Function of Senile Dementia Patients and Its Effect on Related Factors
摘要
Abstract
Objective:To observe the improvement effect of the ginkgo biloba extract on the cognitive function in the patients with senile dementia,and discuse its mechanism.Methods:A total of 80 senile dementia patients in our hospital during in January 2013-January 2014 were randomly divided into control group and observation group,40 cases in each group.Both of the two groups orally took Donepezil HCL,once a day,10 mg/time.The observation group additionally had ginkgo biloba extract injection on these basis,both two group had continuous treatment for 3 months and then compare the two groups′mini-mental state examination (MMSE),clock drawing task (CDT),activity of daily living (ADL)before treatment,and 1 month and 3 months after treat-ment,as well as detect two groups′concentration changes of iconic proteins cAMP,PKA and CREB in patients with peripheral ser-um cAMP-PKA-CREB signaling pathways before and after treatment.Results:1)Integral differences of MMSE,CDT and ADL were showed no statistical significance in the two groups after the treatment (P >0.05),the MMSE,CDT and ADL integral rose after 1 month′s treatment in the two groups (P <0.05),but there was no statistically significant differences between the two groups (P >0.05);and 3 months after treatment,MMSE,CDT,ADL integral of the two groups further improved,which the im-provement extent of observation group was significantly higher than the control group,the differences were statistically significant (P <0.05 ).2)The cAMP,PKA concentration detected by Elisa method,and CREB concentration by Western blotting test showed no statistically significant differences between the two groups (P >0.05),but 3 months after treatment,cAMP,PKA,and CREB protein concentrations in peripheral blood in the treatment group were significantly higher than that of control group (P <0.05).Conclusion:Ginkgo biloba extract can improve the cognitive ability in patients with senile dementia,the mechanism may be related to cAMP-PKA-CREB signaling pathways.关键词
阿尔茨海默病/认知功能/银杏叶提取物/cAMP-PKA-CREB信号通路Key words
Senile dementia/Cognitive function/Ginkgo biloba extract/cAMP-PKA-CREB signaling pathways分类
医药卫生引用本文复制引用
黄建申,沈英生,黄金武..银杏叶提取物对阿尔茨海默病患者认知功能的效果及其对相关因子的影响[J].世界中医药,2016,11(12):2630-2633,4.基金项目
国家自然科学基金青年项目 （）
