世界中医药2016，Vol.11Issue(12)：2678-2681,4.DOI:10.3969/j.issn.1673-7202.2016.12.040
银丹心脑通软胶囊辅助治疗急性脑梗死患者对血清hs-CRP、TNF-α和 IL-6的影响及疗效观察
Yindanxinnaotong Capsule as Adjuvant Therapy in Acute Cerebral Infarction on Serum Hs-CRP,TNF-αand IL-6:A Clinical Observation
摘要
Abstract
Objective:To investigate the efficacy of the treatment in patients with acute cerebral infarction with Yindanxinnaootong capsule,and the influence on serum hs-CRP,TNF-αand IL-6.Methods:Totally 70 cases of acute cerebral infarction were ran-domly collected from July-2016 to July 2015,and were randomly divided into a study group and a control group with 35 cases in each.Two groups of patients were given conventional treatment,and also Aspirin Enteric-coated Tablets orally,100 mg each time, once per day;piracetam orally,0.8 g each time,3 times per day;edaravone injection,30 mg each time,twice per day.Besides, the study group was combined with Yindanxinnaotong capsule,oral administration,3 tablets,3 times per day.Two groups of pa-tients were treated for 2 weeks.The serum levels of hs-CRP,TNF-αand IL-6 were detected in two groups before treatment,after 1 week of treatment and 2 weeks,and the MESS score and Barthel index score were evaluated.Results:1)The Barthel index and MESS score of the two groups were significantly improved (P <0.05),but the improvement of the study group was significantly better than that of the control group.2)The serum levels of hs-CRP,TNF-αand IL-6 were significantly decreased (P <0.05)in 1 and 2 weeks of treatment,but the 3 indexes in the study group were significantly lower than those of the control group (P <0.05).3)The total effective rate of the study group at 1 week was 68.6% and 85.7% at 2 weeks,which was both significantly higher than that of the control group (54.3% and 74.3%)(P <0.05).There were no serious adverse drug events in the two groups during the treatment.Conclusion:Yindanxinnaotong capsule inhibits the inflammatory injury of acute cerebral infarction, and can effectively improve the patient′s neurological symptoms and function of pursuing daily activity.关键词
急性脑梗死/炎性反应因子/银丹心脑通软胶囊Key words
Acute cerebral infarction/Inflammatory factor/Yindanxinnaotong capsule分类
医药卫生引用本文复制引用
张新恒,王丽..银丹心脑通软胶囊辅助治疗急性脑梗死患者对血清hs-CRP、TNF-α和 IL-6的影响及疗效观察[J].世界中医药,2016,11(12):2678-2681,4.基金项目
安徽省自然科学基金面上项目 （）
