世界中医药2016，Vol.11Issue(12)：2682-2684,2688,4.DOI:10.3969/j.issn.1673-7202.2016.12.041
参附注射液联合化疗对中晚期非小细胞肺癌患者造血功能及机体免疫功能的影响
Effects of Shen Fu Injection Combined with Chemotherapy on Hematopoietic and Immune Function in Patients with Middle and Advanced Non-small Cell Lung Cancer
摘要
Abstract
Objective:To investigate the effect of Shen Fu injection combined with chemotherapy on hematopoietic and immune function in patients with middle and advanced non-small cell lung cancer (NSCLC).Methods:Totally 92 patients with middle and advanced NSCLC were randomly divided into the control group and the observation group,46 cases in each.The control group was treated with cisplatin combined with paclitaxel (TP)chemotherapy,and the observation group was with the combination of intrave-nous infusion of 60 mL/d.Both of the 2 groups were carried out for 4 cycles of chemotherapy.The changes of hematopoietic func-tion,humoral immunity and cellular immune function in 2 groups were detected and compared after chemotherapy.Results:Com-pared with those before chemotherapy,levels of peripheral white blood cell (WBC),hemoglobin (Hb)and platelet (PLT)of both groups increased firstly and then decreased after 1 week of chemotherapy till the end.And for the observation group,the level of WBC in peripheral blood was significantly higher than that of the control group (P <0.05 or P <0.01),and Hb and PLT level compared with the level of control group had no significant difference,but there was still significant difference with those before chemotherapy (P <0.05);in control group,the levels of serum IgG,IgA and IgM after chemotherapy and CD3 +,CD4 +T cell ratio and CD4 +/CD8 + all decreased,and the percentage of T cells in CD8 + increased (P <0.05 or P <0.01);while in the ob-servation group,levels of serum IgG,IgA and IgM,CD3 +,CD4 +T cell ratio and CD4 +/CD8 + ratio increased significantly,and the proportion of CD8 + T cells decreased significantly (P <0.05 or P <0.01);in addition,the observation group had less rate of leukopenia,nausea and vomiting and other adverse reaction than the control group (P <0.01).Conclusion:Shen Fu injection can effectively reduce the bone marrow suppression and immune suppression in NSCLC patients with chemotherapy drugs,restore the body′s hematopoietic function,and effectively improve the body′s humoral and cellular immune function.关键词
参附注射液/非小细胞肺癌/化疗/造血功能/免疫功能Key words
Shen Fu Injection/Non-small cell lung cancer/Chemotherapy/Hematopoietic function/Immune function分类
医药卫生引用本文复制引用
杨静,李栋..参附注射液联合化疗对中晚期非小细胞肺癌患者造血功能及机体免疫功能的影响[J].世界中医药,2016,11(12):2682-2684,2688,4.基金项目
徐州市中心医院博士科研基金项目（编号XZB201617）；江苏省中医药局科技项目 （）
