世界中医药2016，Vol.11Issue(12)：2685-2688,4.DOI:10.3969/j.issn.1673-7202.2016.12.042
疏肝健脾法治疗腹泻型肠易激综合征肝郁脾虚证的临床观察及对血清脑肠肽水平的影响
Clinical Observation on therapy of Soothing the Liver and Strengthening the Spleen in Diarrhea-Predominant Irritable Bowel Syndrome(IBS-D)of Liver Depression and Spleen Deficiency Syndrome and Its Influence on Serum Brain-gut Peptide Level
摘要
Abstract
Objective:To investigate the clinical effect of soothing the liver and strengthening the spleen therapy on diarrhea-pre-dominant irritable bowel syndrome (IBS-D)of liver depression and spleen deficiency syndrome and its effect on serum brain-gut peptide level.Methods:Seventy patients with IBS-D were randomly divided into an observation group (n =35 )and a control group (n =35).The control group was treated with conventional western medicine,and the observation group was provided addi-tional self-made Shuganjianpi Decoction for treatment,both for 4 weeks.The levels of 5-serotonin (5-HT),calcitonin gene-related peptide (CGRP),serum substance (SP)and neuropeptide Y (NPY)in the 2 groups were compared before and after treatment, and the clinical effective rate and recurrence were analyzed.Results:After treatment,the level of serum 5-HT,CGRP,SP,NPY in both of the 2 groups were lower than before treatment,and those of the observation group was lower than those of the control group (P <0.01);The clinical symptoms integral of the 2 groups were lower than that before treatment,and the improvement of abdominal pain,diarrhea,abdominal distension and fatigue in the observation group were significantly gtreater than those in the control group (P <0.01);The total effective rate was 91.42% in the observation group,which was significantly higher than that in the control group (71.42%)(P <0.05).During follow-up,2 cases (6.25%)relapsed in the observation group,while 8 (32%)in the control group and there was significant difference between the 2 groups (P <0.05).Conclusion:Shuganjianpi de-coction combined with western medicine can significantly decrease the levels of serum 5-HT,CGRP,SP and NPY in patients with IBS-D,and improve clinical symptoms with a low relapse rate,showing good clinical efficacy.关键词
肠易激综合征/疏肝健脾法/肝郁脾虚证/脑肠肽Key words
Irritable bowel syndrome/Shuganjianpi therapy/Liver depression and spleen deficiency syndrome/Brain-gut pep-tide分类
医药卫生引用本文复制引用
汪正芳,贾玉,侯亚男..疏肝健脾法治疗腹泻型肠易激综合征肝郁脾虚证的临床观察及对血清脑肠肽水平的影响[J].世界中医药,2016,11(12):2685-2688,4.基金项目
国家自然科学基金青年项目（编号81302949）；北京市中医药科技发展资金项目（编号JJ2014-35）；北京市医院管理局“青苗”计划专项经费资助 （）
