山西医科大学学报2017，Vol.48Issue(1)：47-53,7.DOI:10.13753/j.issn.1007-6611.2017.01.011
肿瘤家族史与癌症患者预后相关性的Meta分析
Correlation of family history with prognosis of patients with cancer:a Meta analysis
崔熙娟 1陈硕 2金犇 2杨薇粒 2单涛 2龙泳1
作者信息
- 1. 第四军医大公共卫生学院流行病学教研室，西安 710032
- 2. 西安交通大学医学院第二附属医院普外科
- 折叠
摘要
Abstract
Objective To evaluate the effect of family history of cancer on survival. Methods MEDLINE, CANCERLIT,and Co-chrane library were searched of retrieving the studies up to June 2014. Meta analysis was performed to estimate hazard ratio(HR) and 95% confidence interval( CI) for overall survival( OS) , recurrence-free survival( RFS) ,or the disease-free survival ( DFS) with ran-dom-effects model. Sensitivity and subgroup analyses were also conducted in the Meta analysis. Homogeneity of effects across studies was assessed using χ2 test and quantified by I2 . Results A total of 30 studies were eligible for the Meta analysis. Patients with a family history of cancer had better overall survival(HR=0. 94, 95%CI 0. 87-1. 02). When there was one affected family member in a first-degree family history of cancer, HR was 0. 99(95%CI 0. 84-1. 17); and when there were≥2 affected family members in a first-degree family history of cancer, HR was 1. 10(95%CI 0. 75-1. 62). In addition, HR was 0. 79(95%CI 0. 55-1. 15) for DFS and 0. 83(95%CI 0. 63-1. 08)for RFS. In population distribution, compared with the American and European(HR=0. 96,95%CI 0. 91-1. 01),the positive family history was a protective factor for the Asian (HR=0. 93, 95%CI 0. 90-0. 97). Similarly, the survival showed no difference in patients with family history of gastric cancer(HR=0. 94,95%CI 0. 84-1. 05),urinary cancer(HR=1. 22, 95%CI 1. 00-1. 48)or respiratory cancer(HR=0. 88,95%CI 0. 72-1. 08). Conclusion This Meta analysis of observational stud-ies provides strong evidence that family history of cancer and the number of affected family members are not significantly associated with survival of cancer patients after surgery. While, it suggests that patients with family history of cancer have no effects on survival of DFS and RFS. In population distribution, family history of cancer is a better survival mark in the Asian than those in the American and Eu-ropean. Family history of cancer does not affect the survival of patients with different cancers.关键词
肿瘤家族史/Meta分析/预后/生存率Key words
family history/Meta analysis/prognosis/survival分类
医药卫生引用本文复制引用
崔熙娟,陈硕,金犇,杨薇粒,单涛,龙泳..肿瘤家族史与癌症患者预后相关性的Meta分析[J].山西医科大学学报,2017,48(1):47-53,7.
