实用医学杂志2017，Vol.33Issue(1)：115-117,3.DOI:10.3969/j.issn.1006-5725.2017.01.031
不同剂量右美托咪啶对60岁以上髋部手术患者的脑保护效应
Cerebral protective efficacy of different doses of dexmedetomidine for ederly patients over 60 years with hip operation
邓金和 1贺繁荣 2招伟贤3
作者信息
- 1. 510120 广州市，广州中医药大学第二附属医院麻醉科
- 2. 510602 广州市，解放军四五八医院妇产科
- 3. 510120 广州市，广州中医药大学第二临床医学院
- 折叠
摘要
Abstract
Objective To investigate the Cerebral protective effects of different dosage of Dex for patients over 60 yeas old undergoing selected hip replacement surgery. Methods 80 elderly patients over 60 years old with selected hip replacement surgery in spinal anesthesia were randomly divided into 4 groups: blank control D0 group(no Dex used);D1,D2 and D3 groups,in each group Dex was intravenous infused at the rate of 0.5,0.75 and 1.0 μg/(kg · h) ,respectively after spinal anesthesia.Venous blood was extracted preoperatively ,intraoperatively (after skin incision 1 h) and postoperatively respectively to detect TNF⁃α,IL⁃10 ,NSE and S100β and Montreal cognitive function assessment was conducted at the same time. Results The intraoperative and postoperative levels of IL⁃10 of the four groups increased gradually,especially in the D3 group,and the difference among the four groups was significant (P<0.05). Intraoperative and postoperative plasma concentration levels of NSE and S100βin each groups increased gradually more than that of preoperation ,especially the D0 group in which the increasement was more significant than D2 and D3 group (P<0.05). The MoCA score of the D3 group in the postoperative 1 d and 7 d was the highest,and the difference among the four groups was significant(P < 0.05). Conclusion Intraoperative intravenous infusion of Dex has a certain brain protective effect on ederly patients over 60 years old with hip replacement surgery in spinal anesthesia,while effect of the rate of 1.0μg/(kg·h) is the most obvious.关键词
髋部手术/右美托咪啶/脑保护/术后认知功能Key words
Hip surgery/Dexmedetomidine/Cerebral protection/Postoperative cognitive function引用本文复制引用
邓金和,贺繁荣,招伟贤..不同剂量右美托咪啶对60岁以上髋部手术患者的脑保护效应[J].实用医学杂志,2017,33(1):115-117,3.
