实用医学杂志2017，Vol.33Issue(2)：181-184,4.DOI:10.3969/j.issn.1006-5725.2017.02.004
奈达铂加氟尿嘧啶同期放疗与顺铂同期放疗治疗局部晚期鼻咽癌的疗效比较
Nedaplatin plus fluorouracil combined with radiotherapy compared with cisplatin combined with radio-therapy in the treatment of locally advanced nasopharyngeal carcinoma
马雄辉 1王晓慧 2修良昌 3夏云飞2
作者信息
- 1. 524023 广东医学院附属医院肿瘤科
- 2. 510060 广州市，中山大学肿瘤防治中心放疗科
- 3. 523808 广东省东莞市，广东医学院公共卫生学院
- 折叠
摘要
Abstract
Objective Combination of chemotherapy regimens and chemoradiotherapy to the curative effect of locally advanced nasopharyngeal carcinoma is unclear. The carcinoma radiotherapy adverse reaction and curative effect were investigated in nedaplatin plus fluorouracil in the same period radiotherapy(Group NF)compared with cisplatin(DDP)in the same period (Group DDP)in the treatment of locally advanced nasopharyngeal. Method Patients with locally advanced(ⅢandⅣB)nasopharyngeal carcinoma(NPC)in Sun yat⁃sen university cancer hospital were enrolled and divided into two groups:222 cases in the NF group and 165 cases in the DDP group. The adverse reaction,5⁃year progression⁃free survival(PFS)and overall survival(OS)for 5 years were evaluated in two groups. Results The 5⁃year PFS in the NF and DDP group was 85.13%and 82.42%,respectively, with no significant difference. The 5⁃year OS in the NF and DDP group was 85.58% and 82.42%,respectively, with no significant difference. The proportion of oral mucositis in the NF group was significantly lower than that in the DDP group. Conclusion Nedaplatin plus fluorouracil radiation therapy has similar curative effect ,adverse reaction with cisplatin plus the same radiation therapy in the treatment of locally advanced nasopharyngeal carcinoma.关键词
鼻咽癌/奈达铂/顺铂/同期放化疗Key words
Locally advanced nasopharyngeal carcinoma/Nedaplatin/Cisplatin/Concurrent chemotherapy引用本文复制引用
马雄辉,王晓慧,修良昌,夏云飞..奈达铂加氟尿嘧啶同期放疗与顺铂同期放疗治疗局部晚期鼻咽癌的疗效比较[J].实用医学杂志,2017,33(2):181-184,4.
