实用医学杂志2017，Vol.33Issue(2)：227-230,4.DOI:10.3969/j.issn.1006-5725.2017.02.016
河北汉族人群白细胞介素-17血清表达水平及基因多态性与乙型肝炎病毒感染的关系
Relationship between interleukin-17 gene polymorphisms and outcomes of hepatitis B virus infection in He-bei Han population
摘要
Abstract
Objective To explore the relationship between the polymophisms of interleukin⁃17 (IL⁃17)⁃197A/G and the outcomes of hepatitis B virus (HBV) infections. Methods The polymorphism of genotypes and al⁃leles of IL⁃17⁃197A/G in 222 chronic HBV infected patients and 88 HBV infected ones as controls. The contains of serum HBV DNA were detected using PCR combined with DNA amplification in vitro, serum IL⁃17 expression was detected with ELISA and genotype and allele frequency of IL⁃17⁃197A/G locus was detected by Beckman SNP kit. Results There was a significant difference in the serum IL⁃17 expression (F=158.1, r2=0.61, P<0.000 1) among all the groups. For IL⁃17⁃197A/G, there were significant differences for the comparison between the two groups, and the frequency of AA genotype was 47.72%in liver cirrhosis group. Moreover, the highest frequency of GG was in HBV clear⁃ance group (74.81%);and the lowest group was in chronic HBV liver cirrohosis group (19.05%). Conclusion IL⁃17⁃197A/G AA genotype and allele might be associated with susceptibility of HBV infection in Han population in Hei⁃bei Province.关键词
白细胞介素-17/单核苷酸基因多态性/乙型肝炎病毒/河北汉族Key words
Interleukin-17/Gene polymorphism/Hepatitis B virus/Hebei Han population引用本文复制引用
何培元,侯志平,王春青,尹春英,王艳玲,李炳庆..河北汉族人群白细胞介素-17血清表达水平及基因多态性与乙型肝炎病毒感染的关系[J].实用医学杂志,2017,33(2):227-230,4.基金项目
河北省卫生厅基金资助项目（编号20120162）；河北省临床优秀人才项目（编号361008）；河北省高校重点学科建设项目 （）
