天津中医药2017，Vol.34Issue(2)：94-98,5.DOI:10.11656/j.issn.1672-1519.2017.02.07
热毒清对肝衰竭肠源性内毒素血症的影响
Effect of Reduqing to intestinal endotoxemia in hepatic failure
摘要
Abstract
Objective] To investigate the efficacy of “extracorporeal blood purification”combining with “blood purification in vivo”chinese drugs pharmaceutics “Reduqing” in the treatment on intestinal endotoxemia of hepatic failure. [Methods] The 50 cases of hepatic failure were distinguished by using a single application of “extracorporeal blood purification” (group I), the application of“Reduqing”before“extracorporeal blood purification”(groupⅡ) and“Reduqing”added during the treatment of“extracorporeal blood purification”(groupⅢ). Levels of plasma endotoxin (ET), lipid peroxide (LPO), tumor necrosis factorα(TNF-α), total bilirubin (TBIL) and mortality were observed before and after treatment. [Results] Incidence of endotoxemia in hepatic failure patients was 100%, levels of ET, LPO and TBIL decreased more significantly than before treatment in three groups of liver failure patients, compared with before treatment, TNF-αin groupⅡdecreased significantly after treatment. ET, LPO and TNF-αin groupⅡdecreased significantly than the groupⅠ, groupⅢ. Although the general average of TBIL in groupⅡwas the lowest, the difference between two other groups was not statistically significant (P>0.05). Mortality in groupⅠandⅢwere 75%and 68.75% respectively, and in groupⅡwas 44.44%. Although the mortality in groupⅠand Ⅲ decreased, differences were not statistically significant (P>0.05). [Conclusion] There were different degrees of endotoxemia in patents in liver failure group.“In vivo and extracorporeal blood purification”therapy, whether used alone or in combination, plays a significant role in improving ETM and reduce the inflammatory in hepatic cells. “Reduqing” combining with“extracorporeal blood purification”used in early stage is contributed to a lower ET, reducing LPO and TNF-α. It can also improve liver function, and has a positive significance on reducing mortality by using in early stage.关键词
肝衰竭/肠源性内毒素血症/体内血液净化/体外血液净化Key words
hepatic failure/intestinal endotoxemia/extracorporeal blood purification/blood purification in vivo分类
医药卫生引用本文复制引用
陈鹏,曹武奎..热毒清对肝衰竭肠源性内毒素血症的影响[J].天津中医药,2017,34(2):94-98,5.基金项目
天津市卫生局重点科技基金（09KY03）。 （）
