现代妇产科进展2017，Vol.26Issue(2)：86-90,5.DOI:10.13283/j.cnki.xdfckjz.2017.02.002
血清CA125预测卵巢上皮癌治疗后复发的Meta分析
The value of serum CA125 in predicting ovarian cancer recurrence after treatment:a meta analysis of diagnostic tests
摘要
Abstract
Objective:To evaluate the diagnostic value of serum CA125 levels on ovari-an cancer recurrence after treatment ( operation and chemotherapy ) . Methods:PubMed, EM-BASE,Cochrane Library,Web of Science,CBM,CNKI,IFCC,Medion,CRDdatabase,Bandlier Knowledge library and grey literatures were searched from database building to Dec. 31,2015. Articles of prospective or retrospective cohort studies related to the diagnostic value of serum CA125 on ovarian cancer recurrence were selected. Documents quality were evaluated by the di-agnostic test accuracy quality evaluation tools ( QUADAS ) , any studies meet the requirements were extracted,data analysis was conducted by Meta-Disc 1. 4 software. Results:33 studies with a total of 2188 ovarian cancer cases ( patients) were included. The meta-analysis showed that the diagnostic odds ratio of serum CA125 level on epithelial ovarian cancer recurrence after treatment was 11. 77(95%Cl=7. 16 ~19. 37),sensitivity was 67%(95%Cl=65% ~70%) and specificity was 83%(95%Cl=80% ~85%),positive likelihood ratio was 3. 83(95%Cl=2. 70~5. 43) and negative likelihood ratio was 0. 41(95%Cl=0. 35~0. 49). Conclusion:The negative result of serum CA125 used to rule out ovarian cancer recurrence is more reliable while the positive result to detect recurrence still need to be confirm.关键词
CA125/卵巢上皮癌/复发/Meta分析Key words
CA125/Ovarian cancer/Recurrence/Meta-analysis分类
医药卫生引用本文复制引用
廖胜斌,计峰,陈昌贤,李力..血清CA125预测卵巢上皮癌治疗后复发的Meta分析[J].现代妇产科进展,2017,26(2):86-90,5.基金项目
教育部高校博士学科点专项基金(No:20124503110003) （No:20124503110003）
