中国当代儿科杂志2017，Vol.19Issue(2)：137-141,5.DOI:10.7499/j.issn.1008-8830.2017.02.002
肺表面活性物质联合布地奈德预防极低出生体重儿支气管肺发育不良的疗效观察
Clinical efifcacy of pulmonary surfactant combined with budesonide for preventing bronchopulmonary dysplasia in very low birth weight infants
摘要
Abstract
ObjectiveTo explore the clinical efifcacy of intratracheal instillation of pulmonary surfactant (PS) combined with budesonide for preventing bronchopulmonary dysplasia (BPD) in very low birth weight (VLBW) infants. MethodsThirty VLBW infants with gestational age <32 weeks who developed neonatal respiratory distress syndrome (NRDS) (grade III-IV) suffering from intrauterine infection were randomly assigned into a PS + budesonide group and a PS alone group. The changes were compared between the two groups in arterial blood gas indexes, oxygenation index (OI), duration of mechanical ventilation, duration of oxygen supplementation, incidence of BPD, mortality rate at 36 weeks corrected gestational age and incidences of other complications except BPD.ResultsCompared with the PS alone group, the PS+budesonide group had a lower incidence of BPD, shorter duration of mechanical ventilation and oxygen supplementation (P<0.05). On the 2nd to 6th day after treatment, the PS+budesonide group had higher pH value of arterial blood gas and OI and lower carbon dioxide partial pressure compared with the PS alone group (P<0.05). There were no signiifcant differences in the mortality rate at 36 weeks corrected gestational age and the incidences of other complications except BPD between the two groups (P>0.05).ConclusionsIntratracheal instillation of PS combined with budesonide can effectively reduce the incidence of BPD in VLBW premature infants with severe NRDS.关键词
布地奈德/肺表面活性物质/支气管肺发育不良/极低出生体重儿Key words
Budesonide/Pulmonary surfactant/Bronchopulmonary dysplasia/Very low birth weight infant引用本文复制引用
潘静,陈名武,倪文泉,方涛,张慧,陈冶,潘家华..肺表面活性物质联合布地奈德预防极低出生体重儿支气管肺发育不良的疗效观察[J].中国当代儿科杂志,2017,19(2):137-141,5.基金项目
安徽省自然科学基金项目（No.1608085MH196）；中华儿科杂志珂立苏儿科科研基金项目资助。 （）
