中国免疫学杂志2017，Vol.33Issue(2)：161-169,9.DOI:10.3969/j.issn.1000-484X.2017.02.001
泛素系统在结核分枝杆菌与宿主相互作用中的调控机制研究进展
Regulatory mechanisms of ubiquitin system in Mycobacterium tuberculosis-host interactions
摘要
Abstract
Mycobacterium tuberculosis ( Mtb) is an extremely successful intracellular bacterial pathogen that engages multiple strategies to escape host immune surveillance,so as to survive within host macrophages for long period. Upon the invasion of pathogenic bacteria,the host ubiquitin system plays a critical role in activating the host innate immune responses and associated signaling pathways such as inflammatory and immune responses, autophagy, phagosome maturation and cell death, etc. On the other hand, recent studies have demonstrated that intracellular pathogenic bacteria such as Mtb can secrete a variety of effector proteins into host cells to hijack or co-opt the ubiquitin system to suppress host immune responses. Those pathogen-host interacting interfaces could provide potential novel targets for the development of anti-tuberculosis drugs.关键词
泛素系统/结核分枝杆菌/巨噬细胞/天然免疫/信号通路/效应蛋白Key words
Ubiquitin system/Mycobacterium tuberculosis/Macrophage/Innate immunity/Signaling pathway/Effector proteins分类
医药卫生引用本文复制引用
柴琪瑶,刘翠华..泛素系统在结核分枝杆菌与宿主相互作用中的调控机制研究进展[J].中国免疫学杂志,2017,33(2):161-169,9.基金项目
本文受国家自然科学基金(No.81371769,81571954)、国家973基础科学项目(2014CB744400)和中国科学院“青年创新促进会优秀会员”项目(Y12A027BB2)资助。 （No.81371769,81571954）
