中国药理学通报2017，Vol.33Issue(2)：149-152,153,5.DOI:10.3969/j.issn.1001-1978.2017.02.001
肝窦内皮细胞在肝脏疾病中的作用
Roles of liver sinusoidal endothelial cells in liver diseases
摘要
Abstract
Liver sinusoidal endothelial cells (LSECs) are the highest proportion of liver non-parenchymal cells with fenestrae structure and high endocytic ability maintaining liver homeostasis and playing an indispensable role in the physiology and patholo-gy of the liver.LSECs are involved in the regulation of patholog-ical process in nonalcoholic fatty liver disease(NAFLD),alco-holic fatty liver(AFL),hepatocellular carcinoma(HCC),liverregeneration and liver fibrosis mainly via antiinflammation,endocytosis,secretion of angiocrine signals and maintaining thequiescence phenotype of HSCs.This review highlights the physiological function of LSECs and the different roles in different pathological conditions,which aims to provide a new perspectivefor the treatment of liver diseases through targeting LSECs.关键词
肝窦内皮细胞/肝窦毛细血管化/非酒精性脂肪肝/酒精性脂肪肝/肝细胞性肝癌/肝再生/肝纤维化Key words
LSECs/capillarization/NAFLD/AFL/HCC/liver re-generation/liver fibrosis分类
医药卫生引用本文复制引用
张晨曦,卞勉励,陈星燃,赵士峰,金欢欢,陈琴,张峰,郑仕中..肝窦内皮细胞在肝脏疾病中的作用[J].中国药理学通报,2017,33(2):149-152,153,5.基金项目
国家自然科学基金资助项目（No 81270514，31401210，31571455）；江苏省自然科学基金青年基金（No BK20140955）；江苏省高校自然科学研究面上项目（No 14KJB310011）；2013年江苏高校优秀科技创新团队计划；江苏高校优势学科建设工程资助项目（No ysxk-2010）；南京市医学科技发展项目 （）
