中国药理学通报2017，Vol.33Issue(2)：180-184,5.DOI:10.3969/j.issn.1001-1978.2017.02.008
复方总黄酮对 ApoE 基因敲除小鼠动脉粥样硬化的影响
Effect of compound flavonoids on atherosclerosis in ApoE -/- mice
摘要
Abstract
Aim To investigate the protective effect of compound total flavonoids on atherosclerosis in ApoE -/- knockout mice.Methods Seven-week old C57BL/6 mice considered of the normal group (n =1 5 );seven-week old ApoE -/- mice were fed with high-fat diet and were assigned randomly into 5 groups:model group,simvastatin group,the low com-pound flavonoids group,the middle compound fla-vonoids group and the high compound flavonoids group.After 1 6 weeks,mice serum and aortas were harvested.The formation of atherosclerotic plaque was analyzed by HE staining,The serum level of lipids pro-files and superoxide dismutase (SOD )were deter-rnined.The levels of IL-1 βand NF-κB in serum were detected by ELISA assay.Results Area of atheroscle-rotic lesion was significantly less in the compound fla-vones group than in model.The level of TC,TG,LDL-C,IL-1 β,NF-κB in serum of the compound flavonoids group were decreased significantly,while SOD and HDL-C increased significantly compared with the mod-el group,and the difference was significant (P <0.05).Conclusion The compound flavonoids have a good protective effect on early atherosclerosis in mice, which may be due to its alleviating effects on hyperlipi-demia and inflammation and oxidation.关键词
ApoE 基因敲除小鼠/动脉粥样硬化/复方总黄酮/脂质代谢/斑块/炎症Key words
ApoE knockout mice/atherosclerosis/compound flavonoids/lipid metabolism/plaque/in-flammation分类
医药卫生引用本文复制引用
祝晓庆,杨洁,邵娟,刘超,吴基良..复方总黄酮对 ApoE 基因敲除小鼠动脉粥样硬化的影响[J].中国药理学通报,2017,33(2):180-184,5.基金项目
国家自然科学基金资助项目 （）
