中国药业2017，Vol.26Issue(1)：35-38,4.DOI:10.3969/j.issn.1006-4931.2017.01.012
血液灌流技术与药物治疗有机磷中毒疗效的相关性研究
Relationship between Hemoperfusion and Efficacy of Organophosphorus Poisoning Treatment
景莉 1袁凯锋 1韩丽英 1李晓明1
作者信息
- 1. 西南医科大学附属医院血液内科及中毒急救病房，四川 泸州 646000
- 折叠
摘要
Abstract
Objective To explore the clinical efficacy of hemoperfusion for the organophosphorus poisoning. Methods 95 cases of organophosphate poisoning from September 2010 to September 2014 in the hospital were selected. 32 cases who were poisoned within 12 h and accepted hemoperfusion were selected into group A, 28 cases who were poisoned more than 12 h and accepted hemoperfu-sion were selected into group B, 35 cases who were poisoned and didn't accept hemoperfusion were selected into group C. All groups were treated with the same treatment regimen for organophosphorus poisoning. Group A and B were added with hemoperfusion. The dif-ferences in cholinesterase activity, atropine using and clinical efficacy among the 3 groups were compared. Results Group A and B had higher cholinesterase activity than group C at the time point of 4, 24 and 48 h after treatment ( P ﹤ 0. 01 ) , and group A had higher cholinesterase activity than group B at the time point of 4, 24 and 48 h after treatment ( P ﹤ 0. 01 ); group A and B had shorter 50% cholinesterase recovery time than group C ( P ﹤ 0. 01 );the total atropine dosage, amount of atropine and atropine time in group A and B were both less than those data in C group ( P ﹤ 0. 01 );group A had the shortest average hospital stay in all groups and group C had the longest average hospital stay ( P ﹤ 0. 01 ); there were no significant difference of intermediate syndrome rate among groups ( P ﹥ 0. 05 ); the recovery rate in group A was better than group C ( P ﹤ 0. 05 ) . Conclusion Hemoperfusion has the advantage of shortening cholinesterase recovery time and the total atropine dosage, improving the clinical efficacy in the treatment for organophosphorus poisoning.关键词
有机磷中毒/血液灌流/胆碱酯酶Key words
organophosphorus poisoning/hemoperfusion/cholinesterase分类
医药卫生引用本文复制引用
景莉,袁凯锋,韩丽英,李晓明..血液灌流技术与药物治疗有机磷中毒疗效的相关性研究[J].中国药业,2017,26(1):35-38,4.
