摘要
Abstract
Objective To investigate the influence of maintenance dose DEX on postoperative cognitive function of senile patient with gen-eral anesthesia after gynecological operation. Methods 92 senile patients with general anesthesia in the hospital from March 2014 to March 2016 were selected and divided into group A and group B,46 cases in each group. The two groups were both given the same anes-thesia induction and maintenance dose. Group A was given DEX intravenous infusion 0. 8 μg/kg and maintenance dose 0. 5 μg/(kg·h). Group B was given intravenous infusion intravenous infusion. The NSE,IL-6,CRP,HMGB1,cognitive function and POCD occurrence rate at 24 h before surgery,finish time,24 h,3 d,7 d after surgery and the adverse reactions between two groups were evaluated and com-pared. Results The levels of IL-6 and CRP in two groups at finish time,24 h,3 d,7 d after surgery were higher than those at be-fore;the levels of group B at finish time,24 h,3 d after surgery was higher than those in group A,the difference was statistically sig-nificant ( P ﹤ 0. 05). The levels of NSE and HMGB1 in two groups at finish time,24 h,3 d after surgery were higher than those at before,the levels of NSE and HMGB1 of group B was higher than those in group A,the difference was statistically significant( P ﹤ 0. 05);HMGB1 declined 7 h after surgery but still higher than it at before surgery,the levels of group B was higher than it in group A, the difference of the two groups was statistically significant( P ﹤ 0. 05). The levels of MESS in two groups at 24 h,3 d after surgery was declined,it declined more obviously in group B than that in group A,the difference was statistically significant ( P ﹤ 0. 05). Conclusion DEX can improve cognitive function of senile patients with general anesthesia after gynecological operation and can lower POCD occurrence rate. No severe adverse reactions occurred after surgery. DXE can be seen as an auxiliary anesthetic drug.关键词
维持剂量/右美托咪定/妇科手术/全身麻醉/老年/术后认知功能Key words
maintenance dose/DEX/gynecological operation/general anesthesia/senile/postoperative cognitive function分类
医药卫生
