中国医院用药评价与分析2017，Vol.17Issue(1)：22-24,3.DOI:10.14009/j.issn.1672-2124.2017.01.007
仙灵骨葆胶囊对骨质疏松症患者骨密度和血清Ⅰ型胶原羧基末端交联肽、N端中段骨钙素、骨钙素的影响
Effects of Xianlinggubao Capsules on Bone Mineral Density, Serum β-CTX, N-MID and BGP in Osteoporosis PatientsΔ
摘要
Abstract
OBJECTIVE:To probe into the effects of Xianlinggubao capsules on bone mineral density , serumβ-CTX, N-MID and BGP in osteoporosis patients .METHODS:Randomized controlled trials ( RCT ) were adopted , 50 osteoporosis patients were extracted to be divided into observation group and control group via the random number table , with 25 cases in each.The control group were treated with basic medicine , while the observation group were additionally treated with Xianlinggubao capsules based on the control group , the treatment course was 8 weeks.The bone mineral density, serumβ-CTX, N-MID and BGP level before treatment and after treatment of 6 and 12 months.RESULTS: After treatment of 12 months, the BMD of anterial position of lumbar spine ( L2-4 ) and left neck of femur in observation group were higher than those in control group, with statistically significant difference(P<0.05).After treatment of 12 months, the serum β-CTX level of observation group was lower than that before treatment , and significantly lower than that of control group after treatment of 12 months, with statistically significant difference (P<0.05).After treatment of 6 and 12 months, there were no statistical significance between two groups in serum N-MID level (P>0.05).And the serum BGP level of observation group was higher than that of before treatment , and was respectively higher than that of control group after treatment of 6 and 12 months, with statistically significant difference(P<0.05).CONCLUSIONS:Xianlinggubao capsules combined with basic medicine can effectively improve the BMD in osteoporosis patients , and significantly reduce serum β-CTX level , increasing BGP level;yet it has few effects on N-MID.关键词
骨质疏松症/仙灵骨葆胶囊/骨密度/β-CTX/N-MID/BGPKey words
Osteoporosis/Xianlinggubao capsules/BMD/Serum β-CTx/N-MID/BGP分类
医药卫生引用本文复制引用
曹启辉,曾进海,吉杰,彭雅,付英杰,覃裕..仙灵骨葆胶囊对骨质疏松症患者骨密度和血清Ⅰ型胶原羧基末端交联肽、N端中段骨钙素、骨钙素的影响[J].中国医院用药评价与分析,2017,17(1):22-24,3.基金项目
贵州省中医药管理局中医药、民族医药科学技术研究课题 （）
