中国医院用药评价与分析2017，Vol.17Issue(1)：52-54,3.DOI:10.14009/j.issn.1672-2124.2017.01.018
亚胺培南西司他丁治疗老年肺部感染的疗效观察与药动学研究
Observation on Efficacy of Imipenem Cilastatin in Treatment of Elderly Pulmonary Infection and Pharmacokinetics Study
张风林 1安玉英 1刘洪洲2
作者信息
- 1. 濮阳市人民医院药剂科，河南濮阳 457000
- 2. 濮阳市人民医院呼吸科，河南濮阳 457000
- 折叠
摘要
Abstract
OBJECTIVE:To probe into the efficacy of imipenem cilastatin in treatment of elderly pulmonary infection and the changes of pharmacokinetics parameters .METHODS:84 elderly patients with pulmonary infection admitted into Puyang People's Hospital from Apr .2014 to May 2016 were selected to be divided divided into observation group and control group via the visiting sequence , with 42 cases in each .The control group were treated with cefoperazone sodium and sulbactam sodium , while the observation group received imipenem cilastatin .The clinical efficacy , bacterial clearance rate , incidence of adverse drug reactions of two groups were observed .And changes of imipenem and cilastatin pharmacokinetics were analyzed .RESULTS: The total effective rate of observation group was 95.24%( 40/42 ), significantly higher than that of control group [76.19%(32/42)], with statistically significant difference (P<0.05). The bacterial clearance rate of observation group was significantly higher than that of control group , with statistically significant difference ( P<0.05 ) .There was no statistical significance between two groups in the incidence of adverse drug reactions(P>0.05).The peak concentration of imipenem cilastatin was (27.35 ±0.68) mg/L, the half-life was about 1.0 h.CONCLUSIONS: The efficacy of imipenem cilastatin in treatment of elderly pulmonary infection is remarkable with high safety , and the drug concentration in lung tissue is high with short half -life.关键词
亚胺培南西司他丁/老年肺部感染/药动学Key words
Imipenem cilastatin/Elderly pulmonary infection/Pharmacokinetics分类
医药卫生引用本文复制引用
张风林,安玉英,刘洪洲..亚胺培南西司他丁治疗老年肺部感染的疗效观察与药动学研究[J].中国医院用药评价与分析,2017,17(1):52-54,3.
