中华临床免疫和变态反应杂志2016，Vol.10Issue(4)：320-324,5.DOI:10.3969/j.issn.1673-8705.2016.04.002
鼻部和咽部非变应性炎症对下气道高反应的影响
Effect of Non-allergic Inflammation in Nasal and Pharyngeal Area on Lower Airway Hyperresponsiveness
摘要
Abstract
Objective To investigate the influence of chronic non-allergic inflammation of upper airway muco-sa on responsiveness of lower airway ( bronchial) mucosa.Methods 109 patients with chronic sinusi-tis or chronic tonsillitis were enrolled randomly and divided into two groups: chronic sinusitis group ( n=58 ) and chronic tonsillitis group ( n=51 ) , whereas 50 persons without upper and lower airway mucosa non-allergic inflammation symptoms and signs were also enrolled as negative control .Bronchial provocation test, nasal endoscopy , and allergen skin prick test were performed under normal lung func-tion and exclusion of drug influence, while the test results were compared with the symptoms of patients. Results Based on the results of bronchial provocation test, the positive rate of lower airway mucosa re-sponsiveness of nasal group ( 65.5%) was higher than both of pharyngeal ( 43.1%) and the control group (40.0%), while the positive rate of pharyngeal group was higher than control group.The differ-ences were statistically significant ( P<0.05) .The positive rate of lower airway mucosa responsiveness of nasal group with allergic rhinitis was obviously higher than the other two groups (28/58 vs.8/51, 3/50 ) .Conclusion The chronic inflammation of the upper airway mucosa was correlated with the low-er airway mucosa hyperresponsiveness.The influence of chronic nasal inflammation was more potent than that of the pharyngeal chronic inflammation .The positive rate of lower airway mucosa responsive-ness in nasal group was influenced by concomitant allergic rhinitis significantly .关键词
鼻窦炎/扁桃体炎/鼻炎, 变应性/支气管激发试验/气道高反应Key words
sinusitis/tonsillitis/rhinitis, allergic/bronchial provocation test/airway hyperresponsiveness分类
医药卫生引用本文复制引用
阳玉萍,范宇琴,王燕,雍军,冯娟,张华..鼻部和咽部非变应性炎症对下气道高反应的影响[J].中华临床免疫和变态反应杂志,2016,10(4):320-324,5.基金项目
2015国家自然科学基金面上项目 （）
