中华临床免疫和变态反应杂志2016，Vol.10Issue(4)：340-345,6.DOI:10.3969/j.issn.1673-8705.2016.04.005
P2RX7基因多态性与中国汉族男性原发性痛风的相关性
Association between P2RX7 Gene Polymorphisms and Susceptibility to Primary Gout in a ChineseHan Male Population
摘要
Abstract
Objective The purpose of this study was to investigate the relationship between P 2RX7 gene single nucleotide polymorphisms and primary gout in a Chinese Han male population .Methods The genetic distributions of the single nucleotide polymorphisms rs 2230911 , rs208294 , rs435309 and rs28360447 in P2 RX7 were detected in 219 primary gout patients and 247 controls using SNaPshot technology .Differ-ences in clinical data and polymorphisms between the case and control groups were measured using the Student's t-test andχ2 test.The susceptibility of genotypes and phenotypes to disease was assessed using Logistic regression with odds ratios and 95% confidence intervals . Results There were significant differences in genotypic and allelic frequencies of P 2RX7rs2230911 between cases and controls ( P=0.012 and 0.013 , respectively ) .However , there were no sognificant differences in the other three poly-morphisms .Conclusion Our results suggest that P 2 RX7 rs2230911 may be associated with risk of pri-mary gout in a Chinese Han male population and allele G may be a susceptibility factor for primary gout .关键词
P2RX7/多态性/痛风Key words
P2RX7/polymorphism/gout分类
医药卫生引用本文复制引用
陈勇,应颖,李蓁,黄海燕,龚琼瑶..P2RX7基因多态性与中国汉族男性原发性痛风的相关性[J].中华临床免疫和变态反应杂志,2016,10(4):340-345,6.基金项目
浙江省医药卫生基金（2015KYB346），宁波市第二医院华美研究基金（2015HMKY10），宁波市科技富民惠民项 （）
