中华临床免疫和变态反应杂志2016，Vol.10Issue(4)：346-350,5.DOI:10.3969/j.issn.1673-8705.2016.04.006
IgG4相关疾病与人类白细胞抗原-DR、 DQ等位基因的相关性
Correlation between HLA-DQ, DR Aleles and IgG4-related Diseases
摘要
Abstract
Objective To analyze the correlation between HLA-A DR, DQ alleles and IgG4-related diseases ( IgG4-RD) .Methods HLA-DR, DQ alleles were tested in 91 patients with IgG4-RD and 100 normal controls by polymerase chain reaction-sequence specific primers (PCR-SSP).Results The frequency of HLA-DRB1*03 in IgG4-RD group was much higher than that in control group with significant statistical difference (13%vs.5%, P=0.047); The frequency of HLA-DRB1*09 in IgG4-RD group was much lower than that in control group with significant statistical difference (16% vs.33%, P=0.009).In addition, the gene expression level also showed difference according to different organ involvement .The frequency of HLA-DRB1*03 and HLA-DRB1*08, HLA-DRB1*07 and HLA-DQB1*02, HLA-DRB1*03 and HLA-DQB1*02 , HLA-DRB1*04 , HLA-DRB1*07 and HLA-DQB1*02 , HLA-DRB1*07 HLA-DRB1*03 , HLA-DRB1*07 and HLA-DQB1*02 , HLA-DRB1*08 , as well as HLA-DRB1*04 were higher in patients with of pancreatic gland , submandibular gland , lacriminal gland , parotid , urinary tract, sinus, retroperitoneal fibrosis and lung involvement , respectively.Conclusion Our results suggest that HLA-DRB1*03 might be the susceptible gene in IgG 4-RD.The gene expression also shows differ-ence according to different organ involvement .关键词
IgG4相关疾病/人类白细胞抗原/易感基因Key words
IgG4-related diseases/human leakocyte antigen/susceptible genes分类
医药卫生引用本文复制引用
于立杰,陈雨,张盼盼,张文..IgG4相关疾病与人类白细胞抗原-DR、 DQ等位基因的相关性[J].中华临床免疫和变态反应杂志,2016,10(4):346-350,5.基金项目
国家自然科学基金 （）
