转化医学杂志2017，Vol.6Issue(1)：20-21,31,3.DOI:10.3969/j.issn.2095-3097.2017.01.005
乳腺癌组织中周期素依赖性激酶10基因启动子甲基化状态检测的临床意义
Clinical significance of the cyclin-dependent kinase 10 gene promoter methylation in breast cancer
摘要
Abstract
Objective To investigate the methylation status of the cyclin-dependent kinase 10 ( CDK10) gene promoter in breast cancer. Methods Methylation-specific polymerase chain re-action was performed to observe CDK10 gene promoter methyation in 50 cases of breast cancer ti-ssues companied with their adjacent non-cancerous tissues. The relationship between CDK10 gene methyation and clinical pathological parameters were also analyzed. Results Methylated CDK10 gene was frequently observed in 60. 0% (30/50) of primary tumors,but not in any normal tissue. CDK10 gene methylation was significantly correlated with lymph node metastasis and TNM staging of tumors ( P<0. 05) . Conclusion CDK10 gene methylation may possess a significant function in the development of breast cancer.关键词
周期素依赖性激酶10/DNA甲基化/乳腺癌Key words
Cyclin-dependent kinase 10 ( CDK10)/DNA methylation/Breast cancer分类
医药卫生引用本文复制引用
李文梅,刘佳佳,张印坡,陆建荣..乳腺癌组织中周期素依赖性激酶10基因启动子甲基化状态检测的临床意义[J].转化医学杂志,2017,6(1):20-21,31,3.基金项目
河南省教育厅高等学校重点科研项目应用研究计划(15B320003) （15B320003）
