中山大学学报（医学科学版）2017，Vol.38Issue(1)：78-84,7.
含可待因的止咳药水滥用成瘾患者静息态下全脑白质微结构的改变
Brain Micro-structural Alterations of Cough Syrup Abuse Addiction Patients Containing Codeine Under Resting State
摘要
Abstract
[Objective]To investigate the micro-structural alterations within whole brain white matter(WM) in cough syrup abuse addiction patients containing codeine,and to explore the correlation between aberrant WH and abuse time of cough medicine abuse patients.[Methods]Thirty cough syrup abuse addiction patients containing codeine and 30 controls participated in the study. Structural changes in FA and(mean diffusivity)MD were examined in cough syrup abuse addiction patients containing codeine which derived from DTI tractography. Pearson correlation analysis was performed to compare the mean FA value and duration of cough syrup abuse addiction in patients.[Results]Cough syrup abuse addiction patients containing codeine had lower FA value in bilateral anterior limb of internal capsule(ALIC)and higher MD in the bilateral hippocampus and insula,right anterior cingulate cortex(ACC)and superior temporal gyrus,compared to the controls. Cough syrup abuse addiction group also had positive correlation between mean FAvalues and duration of cough syrup abuse addiction in patients.[Conclusion]Micro-structural alterations within whole brain white matter(WM)are found in cough syrup abuse addiction patients containing codeine. This disturbance progresses as duration increases of cough syrup abuse addiction in patients.关键词
可待因/止咳药水滥用成瘾/脑白质/微结构/静息态/弥散张量成像技术Key words
codeine/cough syrup abuse addiction/white matter(WM)/microstructure/resting state/DTI tractography分类
医药卫生引用本文复制引用
董健卫,王水,马晓芬,江桂华,傅世舜,华克磊,田军章,潘德顺..含可待因的止咳药水滥用成瘾患者静息态下全脑白质微结构的改变[J].中山大学学报（医学科学版）,2017,38(1):78-84,7.基金项目
广东省科技计划项目（2013B021800172），广东省医学科学技术研究基金项目（A2016147），广东省数据科学工程技术研究中心开放项目（2016KF02），广州市人体数据科学重点实验室 （）
