高等学校化学学报2017，Vol.38Issue(2)：275-283,9.DOI:10.7503/cjcu20160650
结冷胶与聚乙二醇丙烯酸酯双网络凝胶的制备及生物相容性评价
Preparation and Properties of Double Network Hydrogels Based on Gellan Gum and Polyethylene Glycol Acrylate?
摘要
Abstract
Hydrogels have the similar 3D micro-environment as the native extracellular matrix and hold great potential in future biomedical applications. However the mechanical performance limited their applications. The double network hydrogel( DN gel) attracts much attention due to its high mechanical properties. This study aimed to prepare a series of DN gels based on gellan gum and polyethylene glycol acrylate ( PEGDA) to improve the toughness of gellan gum hydrogel for 3D cell culture and tissue repair. The DN hydrogels exhibited better mechanical properties, with the tensile fracture energy up to 1. 01 × 103 J/m2 , which was similar to the value of natural articular cartilage. Our study suggests that the DN gel based on gellan gum and PEGDA present promising mechanical performance and cell seeding efficiency. These hydrogels may have prospective applications in the fields of wound dressing, artificial cartilage and tissue engineering scaffold materials which require high mechanical properties.关键词
结冷胶/双网络凝胶/聚乙二醇丙烯酸酯/细胞三维立体培养Key words
Gellan gum/Double network hydrogel/Polyethylene glycol acrylate( PEGDA)/3D cell culture分类
化学化工引用本文复制引用
汪争光,胡朵,吴东蔚,鲁路,周长忍..结冷胶与聚乙二醇丙烯酸酯双网络凝胶的制备及生物相容性评价[J].高等学校化学学报,2017,38(2):275-283,9.基金项目
广东省自然科学基金(批准号:2014A030313379)和国家自然科学基金(批准号:81171459)资助.? Supported by the Natural Science Foundation of Guangdong Province, China(No.2014A030313379) and the National Natural Science Foundation of China( No.81171459) . （批准号:2014A030313379）
