高校化学工程学报2017，Vol.31Issue(1)：7-12,6.DOI:10.3969/j.issn.1003-9015.2016.00.046
普瑞巴林晶型Ⅰ在纯溶剂及丙酮-水混合溶剂中的溶解度测定与关联
Measurement and Correlation of Pregabalin Form Ⅰ Solubility in Pure Solvents and Acetone-Water Mixtures
摘要
Abstract
The solubility of pregabalin form Ⅰ in water, methanol, ethanol, acetone, tetrahydrofuran, N,N-dimethylformamide, ethyl acetate and acetone-water mixed solvents was measured at 283.15~328.15 K by equilibrium methods. The experimental results show that the solubility of pregabalin form Ⅰ in those selected pure solvents and acetone-water mixed solvents increases with the increase of temperature, while it decreases with the increase of mole fraction of acetone in acetone-water mixture. The solubility is close to zero when the mole fraction of acetone in the mixture is ~0.83. The experimental data is well correlated by modified Apelblat empirical equation and (CNIBS)/Redlich-Kister equation, respectively. The solubility data and models obtained are useful for the study of industrial crystallization and drug polymorphism.关键词
普瑞巴林/溶解度/测定/关联/模型Key words
pregabalin/solubility/measurement/correlation/modeling分类
化学化工引用本文复制引用
于玉振,张晓慧,李鹏坤,王荣荣,李战军,刘宇恒,李雯..普瑞巴林晶型Ⅰ在纯溶剂及丙酮-水混合溶剂中的溶解度测定与关联[J].高校化学工程学报,2017,31(1):7-12,6.基金项目
河南省科技厅产学研合作项目(152107000043) （152107000043）
河南省教育厅科学技术研究重点项目(914A5300007). （914A5300007）
