解放军医药杂志2017，Vol.29Issue(2)：52-54,3.DOI:10.3969/j.issn.2095-140X.2017.02.013
子宫内膜复杂性增生中错配修复基因蛋白的表达
A Study on Protein Expressions of Mismatch Repair Genes in Complex Endometrial Hyperplasia
摘要
Abstract
Objective To observe expressions of mismatch repair genes in complex endometrial hyperplasia. Methods A total of 50 samples of complex endometrial hyperplasia were collected, and immunohistochemical method was used to detect protein expressions of mismatch repair genes. Clinical information from case history was obtained and analyzed. Results Among the 50 patients with complex endometrial hyperplasia, 27 patients (54%) had loss of expres-sion of at least one of mismatch repair genes. 18 patients (36%) had loss of expression of two or more mismatch repair genes, and 3 patients (6%) had negative expressions of all the four mismatch repair genes. Conclusion Patients with complex endometrial hyperplasia should be given genetic gene detection more comprehensively, and effective ways should be provided for preventing cancer of endometrium.关键词
子宫内膜复杂性增生/错配修复/基因表达Key words
Complex endometrial hyperplasia/Mismatch repair/Gene expression分类
医药卫生引用本文复制引用
刘彩虹,于淑莉,陈志强,武文杰..子宫内膜复杂性增生中错配修复基因蛋白的表达[J].解放军医药杂志,2017,29(2):52-54,3.基金项目
承德市卫生和计划生育委员会支持基金项目(20160289) （20160289）
