解放军医药杂志2017，Vol.29Issue(2)：103-106,4.DOI:10.3969/j.issn.2095-140X.2017.02.026
CA19-9、CEA、CA242联合检测对胆管癌诊断的评估价值
Values of CA19-9, CEA and CA242 Combined Detection in Evaluation of Diagnosis for Bile Duct Carcinoma
摘要
Abstract
Objective To investigate clinical value of serum carbohydrate antigen 19-9 (CA199), carbohydrate antigen 242 (CA242) and carcinoembryonic antigen (CEA) combined detection in diagnosis of bile duct carcinoma. Methods A total of 52 patients with bile duct carcinoma admitted during January 2012 and October 2015 were selected as observation group, and 52 patients with benign biliary tract diseases admitted at same period were selected as control group. Serum concentrations of CA199, CA242 and CEA and their positive rates were detected using radiation immunoas-say, and values of sensitivity, specificity and positive and negative likelihood ratios and accuracy of combination tumor marker detection of CA199, CA242 and CEA were calculated. Results In observation group, CEA and CA19-9 and CA242 concentrations were significantly higher (P<0. 01), and their positive rates were significantly higher than those in control group ( P <0. 01 ) . Single tumor marker detection showed that CA19-9 sensitivity was the strongest, and CA242 specificity was the highest. Combination tumor marker detection showed that CA19-9 +CEA +CA242 had the strongest sensitivity, and CA19-9+CA242 had the highest in specificity and accuracy. Conclusion Combined detection of CA19-9, CEA and CA242 can significantly improve diagnostic level and detection rate, and decrease missed diagnosis rate of bile duct carcinoma.关键词
胆管癌/糖类抗原199/癌胚抗原/糖类抗原242Key words
Bile duct neoplasms/Carbohydrate antigen 19-9/Carcinoembryonic antigen/Carbohydrate antigen 242分类
医药卫生引用本文复制引用
崔大鹏,张迎春..CA19-9、CEA、CA242联合检测对胆管癌诊断的评估价值[J].解放军医药杂志,2017,29(2):103-106,4.基金项目
张家口市科学技术研究与发展计划自筹项目(1421150D) （1421150D）
