河北医学2017，Vol.23Issue(1)：13-16,4.DOI:10.3969/j.issn.1006-6233.2017.01.005
Ghrelin基因多态性与原发性高血压患者危险因素的关系研究
The Relationship between Ghrelin Gene Polymorphism and Essential Hypertension in Patients with Risk Factors
摘要
Abstract
Objective:To investigate the relationship between the human growth hormone releasing pep-tide ( Ghrelin) and the essential hypertension. Methods:80 cases of patients with essential hypertension were studied and 80 cases of healthy were selected from October 2014 to October. The Ghrelin gene polymorphism assays of two groups were used with TaqMan-PCR method and Ghrelin gene polymorphism in patients with risk factors for hypertension were analyzed. Results:Compared with the control group, patients with hypertension CC, CA, AA genotype frequency distribution was 68.75%, 17.50%, 13.75%, allele C, A frequencies were 0.185,0.875, the control group were 18.75% , 35.00%, 46.25%, allele C, a frequencies were 0.125,0.815. Ghrelin gene CC type serum triglycerides in patients with hypertension ( TC) , low density lipoprotein ( LDL-C), total cholesterol (TG), systolic blood pressure (SBP), diastolic blood pressure (DBP), waist-hip ratio ( WHR) , body mass ( BMI) were significantly higher than those of CA and AA genotype ( P <0.05) , whereas HDL-C and lower than the CA type AA type ( P<0.05) . Chi square and Logistic multivariate analysis showed that the Ghrelin gene type CC was associated with TC abnormalities, LDL-C abnormalities, SBP abnormali-ties, DBP abnormalities, and BMI abnormalities. Conclusion:Ghrelin gene polymorphism and risk factors lead to high blood pressure, such as abnormal TC, LDL-C exception, SBP abnormality, DBP abnormality,BMI and abnormal, and therefore, Ghrelin gene polymorphism may be involved in essential hypertension pathogenesis.关键词
Ghrelin基因多态性/高血压/低密度脂蛋白/发病机制Key words
Ghrelin gene polymorphism/Hypertension/Low-density lipoprotein/Pathogenesis引用本文复制引用
刘斌,周志安,刘丽丽,姜敏,高磊,金明磊..Ghrelin基因多态性与原发性高血压患者危险因素的关系研究[J].河北医学,2017,23(1):13-16,4.基金项目
河北省科技支撑项目,(编号:ZL20140072) （编号:ZL20140072）
