河北医学2017，Vol.23Issue(1)：16-19,4.DOI:10.3969/j.issn.1006-6233.2017.01.006
右美托咪定用于食管癌根治术后PCIA对机体炎症反应的影响
Effects of Dexmedetomidine PCIA on Inflammatory Reaction in Esophageal Cancer Surgery
摘要
Abstract
Objective:To investigate the effects of dexmedetomidine patient-controlled intravenous an-algesia on inflammatory reaction in esophageal cancer surgery. Methods:80 patients ( aged 50~70, ASAⅠ~Ⅱ) scheduled for esophageal cancer surgery were randomly divided into 2 groups ( in each group):morphine group ( group M, n=40) and dexmedetomidine and morphine group ( group DM, n=40) . PCIA were used in both groups after surgery. Group M were pumping morphine with 0. 3mg/kg/h, group DM were pumping dexmedetomidine 1μg/kg/d and morphine 0. 3mg/kg/h, both of them were dilutioned to 150 ml with 0. 9%normal saline.The expressions of IL-1 and TNF-α in venous blood were tested on the preoperative 1 day ( T1 ) , postoperation 6 hour ( T2 )、24 hour ( T3 ) and 72 hour ( T4 ) . And the scores of visual analog scale ( VAS) and the dosage of morphine were evaluated on T2~T4 . Results:Compared with group M, the VAS score, the dosage of morphine and the expressions of IL-6 and TNF-αwere decreased and IL-1 and TNF-αwere increased on T2~T4 in group DM ( P<0.05) . Compared with T1 , the expressions of IL-1 and TNF-αon T2~T4 were increased in two groups ( P<0.05) . Conclusion:The dexmedetomidine can relieve the pain after esophageal cancer surgery, and decrease the dosage of morphine and inflammatory reaction of body.关键词
右美托咪定/吗啡/食管癌根治术/炎症反应Key words
Dexmedetomidine/Morphine/Esophageal cancer surgery/Inflammatory reaction引用本文复制引用
王怡,黄泽清..右美托咪定用于食管癌根治术后PCIA对机体炎症反应的影响[J].河北医学,2017,23(1):16-19,4.基金项目
辽宁省博士启动基金资助项目,(编号:20091045) （编号:20091045）
