河北医学2017，Vol.23Issue(1)：22-27,6.DOI:10.3969/j.issn.1006-6233.2017.01.008
CD133β-catenin及hTERT在胃癌组织中的表达及其临床关联性
Expression of CD133 β-catenin and hTERT in Gastric Carcinoma and the Clinical Relevance
摘要
Abstract
Objective:To study the expression of CD133, β-catenin and hTERT in gastric carcinoma and the clinical relevance. Methods:CD133 β-catenin and hTERT expression in tissue samples of 60 cases of gastric cancer ( group A) , 60 cases of precancerous lesions ( group B) and 40 cases of chronic non-atroph-ic gastritis ( group C) admitted in our hospital from February 2015 to March 2016 were detected by immuno-histochemical method and analyzed. Results:The results of immunohistochemistry showed that the positive rates of CD133, β-catenin and hTERT in gastric cancer and precancerous lesions were significantly higher than those in gastritis, the difference was statistically significant ( P < 0.05) , while the positive rate of gastric cancer was significantly higher than that of cancer precancerous lesion. The expression of A, B group CD133,β-catenin beta and hTERT protein was significantly higher than that in group C, while the A group was signif-icantly higher than that in B group, the differences were statistically significant ( P <0.05);CD133 protein in cancer tissues,β-catenin protein and hTERT protein in higher than that without lymph node metastasis in lymph node metastasis and expression. In the depth of invasion in T3+T4 was higher than that in T1+T2. The difference was statistically significant ( P <0.05) . The correlation analysis showed that the expression levels of CD133, β-catenin and hTERT were positively correlated. Conclusion:The expression of CD133,β-catenin and hTERT are closely related to the stomach cancer occurrence, development, invasion and metastasis, which can be used as a clinical reference indexes of early diagnosis and prognosis of gastric cancer.关键词
胃癌/免疫组织化学/β-连环蛋白/人端粒酶逆转录酶Key words
Gastric cancer/Immunohistochemistry/β- chain protein/Human telomerase re-verse transcriptase引用本文复制引用
戚红霞..CD133β-catenin及hTERT在胃癌组织中的表达及其临床关联性[J].河北医学,2017,23(1):22-27,6.基金项目
上海市闸北区卫生科研面上一般项目,(编号:2014MS04) （编号:2014MS04）
