河北医学2017，Vol.23Issue(1)：111-114,4.DOI:10.3969/j.issn.1006-6233.2017.01.037
镇痛镇静对重症蛛网膜下腔出血患者脑代谢的影响
Effect of Analgesia and Sedation on Cerebral Metabolism in Patients with Severe Subarachnoid Hemorrhage
摘要
Abstract
Objective:To integrative clinical effect of analgesia and sedation on cerebral metabolism in patients with severe subarachnoid hemorrhage. Methods:55 patients with severe subarachnoid hemorrhage were chosen for this investigation. Fentanyl citrate injection, midazolam injection and propofol injection were used for the treatment of severe subarachnoid hemorrhage. The carotid, jugular and central venous oxygen sat-uration before, during and after analgesia and sedation treatment were detected. Results:Before sedation and analgesia treatment, the carotid, jugular and central venous blood oxygen saturation were (0.86±0.19), (0. 46±0.07) and (0.48±0.05). 2h after analgesia and sedation treatment started, carotid artery oxygen satura-tion decreased significantly (t=4.63, P < 0.05); while the jugular vein (t=7.62, P < 0.05) and central vein (t=7.53, P < 0.05) oxygen saturation increased significantly. After analgesia and sedation treatment, carotid artery oxygen saturation decreased, while jugular vein and central venous oxygen saturation increased, and the results had no significant difference with the results before treatment (P > 0.05). Conclusion:The use of analgesia and sedation treatment of patients with severe subarachnoid hemorrhage can not only reduce the body metabolism, but also reduce the cerebral metabolism. Whether analgesia and sedation treatment can improve the prognosis of severe subarachnoid hemorrhage needs further study.关键词
镇痛镇静/重症蛛网膜下腔出血/脑代谢/血氧饱和度Key words
Analgesia and sedation/Severe subarachnoid hemorrhage/Cerebral metabolism/Blood oxygen saturation引用本文复制引用
李深誉,阳永东,严峻,韦开亮,黄蕃俊,陈前,罗朗昭,吴修富..镇痛镇静对重症蛛网膜下腔出血患者脑代谢的影响[J].河北医学,2017,23(1):111-114,4.基金项目
2016年度广西医药卫生自筹经费计划课题项目,(编号:Z2016037) （编号:Z2016037）
