摘要
Abstract
Objective:To investigate the effect of dexmedetomine ( DEX) on close-loop muscle relax-ant injection system using cisatracurium ( CIS) in laparoscopic cholecystectomy ( LC) . Methoyds:60 patients undergoing LC under general anesthesia with tolal intravenous anesthesia were randomly divided into three groups:group A, normal saline ( NS)+3ED95CIS; group B, DEX+3ED95CIS; group C, DEX+4ED95CIS 20 case in each group. In group B and C, a bolus close of 1.0μg/kg DEX was infused before 15 minutes of in-duction, followed by continous infusion of 0.5μg/kg/h untill 20 min before the operation ended. Normal saline was infused in the same way in group A. The onset time, intubation condition, the first-time to add medicine, clinic effect time, the time from stopped close-loop muscle relaxant to recovery of TOF to 0.2,0.5,0.7,0.9, and recovery index ( RI) of CIS. Result:There were no statistical significant on onset time, intubation condi-tion, the first time to add medicine, clinical cluration, the time from stopped close-loop muscle relaxant to re-covery of TOF to 0.2,0.5,0.7,0.9 and RI of CIS in groupAand group B. Comparison between group C and group A, onset time of group C was shorter than in group A (P<0.05), and first add medicine time longer than group A ( P<0.05) . Comparison between group B and group C, onset time of group C shorter than group B, first add medicine time longer than group B ( P<0.05) . The intubation condition in group C was better than in group B ( P<0.05) . Conclusion:DEX can not affect metablism and effect of CIS with closed-loop muscle relaxant injection, but it can improve the condition of intubation. Use DEX conbined with CIS was safe to the patient.关键词
右美托咪定/顺苯阿曲库铵/闭环肌松靶控注射泵Key words
Dexmedetomine/Cisatracurium/Close-loop muscle relaxant injection
