华东理工大学学报（自然科学版）2017，Vol.43Issue(1)：23-28,6.DOI:10.14135/j.cnki.1006-3080.2017.01.004
必特螺旋霉素的工业结晶过程
Crystallization Process of Bitespiramycin
摘要
Abstract
Taking unknown impurities as the focal point,the optimum crystallization pH value was investigated at 25 ℃.The effect of temperature on crystallization process was explored at a certain pH value.Gradient elution was utilized to analyze components and impurities in product.Selectivity coefficients of effective components and total unknown impurities to spiramycin were compared with each other.In view of qualified effective compositions and lower impurities contents,the most suitable terminal pH value of crystallization operation was 7.5-8.0,temperature was 25-35 ℃.The variation of unknown impurities contents was first adopted to explore bitespiramycin crystallization in the existing studies,which would have a profound guiding significance for the practical production.关键词
必特螺旋霉素/结晶pH/选择性系数/杂质Key words
bitespiramycin/crystallization pH value/selectivity coefficient/impurities分类
化学化工引用本文复制引用
牛梦旗,朱家文,陈葵,吴艳阳,杨生武,应喜平..必特螺旋霉素的工业结晶过程[J].华东理工大学学报（自然科学版）,2017,43(1):23-28,6.基金项目
上海市科委生物医药科技重点项目(10431901500) （10431901500）
