华东理工大学学报（自然科学版）2017，Vol.43Issue(1)：50-55,6.DOI:10.14135/j.cnki.1006-3080.2017.01.008
线性-树枝状共聚物载药微球的制备、表征及体外释放
Preparation,Characterization and Release Behavior of Drug-Loaded Microparticles by Linear-Dendritic Diblock Copolymer
杨李影 1郭睿 2戎宗明1
作者信息
- 1. 华东理工大学化学与分子工程学院,上海 200237
- 2. 巴斯夫上海涂料有限公司,上海 201108
- 折叠
摘要
Abstract
The rapamycin-loaded spherical microparticle based on biodegradable linear-dendritic diblock copolymer is prepared by dialysis method.Scanning electronic microscope(SEM),dynamic light scattering (DLS)and UV spectrophotometer were used to investigate morphology,size and in vitro release behavior of these particles.The results showed that the drug content and encapsulation efficiency of drug-loaded microparticles prepared by diblock copolymer,as well as those prepared by dumbbell-shaped triblock copolymer,could be more than 40% and 90%,respectively.Meanwhile,the mean size of those microparticles reduced significantly and it showed an obvious sustained release as well.关键词
线性-树枝状共聚物/生物可降解/载药微球/体外释放/雷帕霉素Key words
linear-dendritic diblock copolymer/biodegradable/drug-loaded microparticles/drug in vitro release/rapamycin分类
化学化工引用本文复制引用
杨李影,郭睿,戎宗明..线性-树枝状共聚物载药微球的制备、表征及体外释放[J].华东理工大学学报（自然科学版）,2017,43(1):50-55,6.
