Abstract
Objective To investigate the quantitative electroencephalogram (QEEG )features of Alzheimer′s disease (AD ) and vascular dementia(VD) and their correlation with cognitive function in the patients with AD and VD .Methods The electroenceph-alogram(EEG) power spectrum analysis was performed on 50 patients with AD ,50 patients with VD and 50 healthy elderly persons (NC) .According to the frequency ,the power spectra were divided into delta wave(0 .5-3 .9 Hz) ,theta wave(4 .0-7 .9 Hz) ,alpha wave(8 .0-13 .9 Hz) ,beta wave(14 .0-30 .0 Hz) ,(delta+ theta)/(alpha+ beta) value served as the observation evaluation index for conducting comparison .The EEG abnormal degree and (delta+ theta)/(alpha+beta) values of whole brain and FP1 ,FP2 ,F3 , F4 ,C3 ,C4 ,P3 ,P4 ,O1 ,O2 ,F7 ,F8 ,T3 ,T4 ,T5 and T6 were compared ,and their correlation with the Mini Mental State Examination Table(MMSE) score was analyzed .Results The incidence rate of moderate and severe abnormal EEG in the AD group was signifi-cantly higher than that in the VD group(χ2 =4 .11 ,P<0 .05) .The (delta+ theta)/(alpha+ beta) values of whole brain and FP1 , FP2 ,F3 ,F4 ,C3 ,C4 ,P3 ,P4 ,O1 ,O2 ,F7 ,F8 ,T3 ,T4 ,T5 and T6 in the AD group were higher than those in the control group ,the difference was statistically significant(P<0 .05) .The (delta+ theta)/(alpha+ beta) values of whole brain ,FP1 ,FP2 ,F4 ,C3 ,C4 , P4 ,O1 ,O2 ,F7 ,F8 ,T3 ,T4 ,T5 in the VD group were higher than those in the control group ,the difference was statistically signifi-cant(P<0 .05) .The (delta+ theta)/(alpha+beta) values of each region had no statistically significant difference between the AD group and VD group(P>0 .05) .The (delta+theta)/(alpha+ beta) values of FP1 ,F3 ,C3 ,F7 ,T3 ,T5 and whole brain left side in the VD group were higher than those of the symmetric area on the right side ,the difference was statistically significant (P<0 .05) . The (delta+ theta)/(alpha+beta) value in the AD group only had statistically significant difference between the whole brain left side and right side(P<0 .05);the (delta+ theta)/(alpha+beta) value had no statistical difference between the whole brain left side and right side and between the left and right symmetrical positions in various regions (P>0 .05) .The MMSE score in the AD group and VD group was negatively correlated with the (delta+theta)/(alpha+beta) value in each region(P<0 .05) .Conclusion QEEG is an objective and quantitative detection method of brain function and has an important value in the diagnosis ,differential diagnosis and cognitive function evaluation of AD and VD .关键词
阿尔茨海默病/血管性痴呆/定量脑电图/认知功能Key words
Alzheimer′s disease/vascular dementia/quantitative EEG/cognitive function
