检验医学与临床2017，Vol.14Issue(5)：637-639,642,4.DOI:10.3969/j.issn.1672-9455.2017.05.014
RTE、FIB-4、APRI对乙型肝炎患者肝纤维化的诊断价值比较
Comparison of diagnostic values of RTE ,FIB-4 and APRI in liver fibrosis of hepatitis B patients
沈伟 1郑梦琳 2郭佳2
作者信息
- 1. 中国人民解放军第五四六医院特诊科 ,新疆马兰841700
- 2. 第二军医大学附属东方肝胆外科医院超声科 ,上海200438
- 折叠
摘要
Abstract
Objective To compare the values of real-time ultrasound elastography(RTE) ,aspartate aminotransferase and platelet ratio index(APRI) and liver fibrosis index based on factor 4(FIB-4) for diagnosing liver fibrosis(LF) .Methods One hundred and four inpatients undergoing hepatectomy or liver puncture biopsy were selected .The correlations between preoperative LF index , APRI and FIB-4 with the pathological stages of liver tissue were compared .The receiver operating characteristic(ROC) curves were drawn for comparing the diagnostic efficiencies of these noninvasive methods in diagnosing different stages of LF .Results The val-ues of LF index ,FIB-4 and APRI showed significantly positive correlations with the pathological stages of LF (P<0 .01) .The areas under ROC curve(AUROC) of LF index were 0 .833 for significant LF(≥S2) ,0 .940 for advanced LF(≥S3) and 0 .907 for early cirrhosis(S4) ,which were significantly higher than 0 .681 ,0 .651 and 0 .714 of APRI ,the differences were statistically significant (P<0 .05) .AUROC of LF index for diagnosing advanced LF was significantly higher than that of FIB-4(0 .822) ,the difference was statistically significant(P<0 .05) .Conclusion RTE has higher diagnostic value for LF of hepatitis and can be applied in clinic for replacing partial liver biopsy .关键词
实时组织超声弹性成像技术/基于4因子的肝纤维化指标/天门冬氨酸氨基转移酶与血小板比值指数/慢性乙型肝炎/肝纤维化Key words
elastography/FIB-4/APRI/chronic hepatitis B/liver fibrosis引用本文复制引用
沈伟,郑梦琳,郭佳..RTE、FIB-4、APRI对乙型肝炎患者肝纤维化的诊断价值比较[J].检验医学与临床,2017,14(5):637-639,642,4.
