临床神经病学杂志2017，Vol.30Issue(1)：13-15,3.
Guillain-Barré综合征患者中枢神经系统内源性免疫反应与脑脊液蛋白的相关性
Correlation between the endogenous immune response in the central nervous system and cerebrospinal fluid protein in patients with Guillain-Barré syndrome
摘要
Abstract
Objective To explore the correlation between the endogenous immune response in the CNS and CSF protein in patients with Guillain-Barré syndrome ( GBS ) . Methods Clinical data of 69 patients with GBS were retrospectively analyzed. IgG and album level in CSF and serum were detected by the way of immune nephelometry. CSF albumin/serum albumin ( QALB) , IgG index, and 24 h intrathecal IgG synthesis rate were calculated. Results There was no significant difference in rate variance of gender, age, disability scale score, upper respiratory tract infection, gastrointestinal infection, pulmonary infection, and recent vaccination between the normal and high level CSF protein patients. CSF protein, QALB, IgG and 24 h intrathecal IgG synthesis rate of normal level CSF protein patients were significantly lower than that of high level CSF protein patients (all P<0. 01). There was no significant difference in IgG index between the two groups. CSF protein of normal 24 h intrathecal IgG synthesis rate patients [0. 49 (10. 84)]g/L was significantly lower than that of high 24 h intrathecal IgG synthesis rate patients [0. 98(12. 97)]g/L (U=205. 50,P<0. 01). The 24 h intrathecal IgG synthesis rate was positively correlated with CSF protein (r=0. 599, P<0. 01). Conclusion The CSF protein increased accompany with the endogenous immune response, and the 24 h intrathecal IgG synthesis rate may be helpful in monitoring and prognosis of GBS.关键词
神经免疫/Guillain-Barré综合征/内源性免疫反应/24hIgG鞘内合成率/CSF蛋白Key words
neural immune/Guillain-Barré syndrome/endogenous immune response/24 h intrathecal IgG synthesis rate/CSF protein分类
医药卫生引用本文复制引用
周月平,朱德生,胡斌,龙琳娟,傅珏..Guillain-Barré综合征患者中枢神经系统内源性免疫反应与脑脊液蛋白的相关性[J].临床神经病学杂志,2017,30(1):13-15,3.基金项目
中国博士后基金面上项目资助课题(2014M560297) （2014M560297）
医学院科技重点项目资助课题(CDFY-KJ1504) （CDFY-KJ1504）
