李滔 1王昌富 1梅冰 1李琳芸 1姚长江 2龚道凯 2胡小辉2
作者信息
- 1. 34020荆州,华中科技大学同济医学院附属荆州医院检验医学部
- 2. 34020荆州,华中科技大学同济医学院附属荆州医院神经内科
- 折叠
摘要
Abstract
Objective To investigate the correlation of P-selectin ( SELP) gene S290N polymorphisms and P-selectin glycoprotein ligand-1 (PSGL-1) gene M62I polymorphisms with ischemic cerebral infarction. Methods One hundred and forty-eight ischemic cerebral infarction patients were in cerebral infarction group, and these patients were divided into large artery atherosclerosis cerebral infarction ( LAA) subgroup, cardioembolism ( CE) subgroup and small artery occlusion cerebral infarction ( SAO ) subgroup. Eighty-eight healthy controls were in normal control group. Polymorphisms of SELP gene S290N and PSGL-1 gene M62I of all subjects were detected by gene sequencing. Results Compared with normal control group, there was no significant difference of frequency of S290N genotype and allele in cerebral infarction group and its subgroup (all P>0. 05). Compared with normal control group, there was significant differences of frequency of M62I genotype and allele in cerebral infarction group (all P<0. 01). Compared with normal control group, there was no significant difference of M62I genotype in LAA subtypes group (χ2=5. 889, P=0. 053). Compared with normal control group, there was significant difference of M62I allele frequency in LAA subgroup (χ2 =6. 156, P=0. 021). Compared with normal control group, there was no significant difference of M62I genotype and allele frequency in CE subgroup (χ2 =1. 693, P=0. 429;χ2 =1. 372, P=0. 238). Compared with normal control group, there were significant differences of M62I genotype and allele frequency in SAO subgroup (χ2 =12. 572, P=0. 002; χ2 =8. 736, P=0. 004). S290N gene had no correlation with the risk of ischemic cerebral infarction (all P>0. 05). However, dominant and over-dominant models of M62I were associated with the risk of ischemic cerebral infarction ( OR =2. 662, 95%CI: 1. 531 -4. 630, P=0. 000; OR =0. 392, 95%CI:0. 219-0. 701, P=0. 001), while recessive and additive models of M62I were not (OR=1. 428, 95%CI:0. 528-3. 862, P= 0. 630; OR = 2. 121, 95% CI: 0. 766 - 5. 872, P= 0. 156). Conclusion PSGL-1 gene M62I polymorphism is correlated with ischemic cerebral infarction.关键词
P-选择素/P-选择素糖蛋白配体-1/缺血性脑梗死/基因多态性/亚型Key words
P-selectin/P-selectin glycoprotein ligand-1/ischemic cerebral infarction/gene polymorphism/subtype分类
医药卫生
