山东中医杂志2017，Vol.36Issue(3)：237-240,4.
夏王散结胶囊提取工艺研究
A Study of the Extraction Technology for Xiawang Sanjie Capsule
摘要
Abstract
Objective:To determine the extraction technology of the Xiawang Sanjie capsule,and to ensure its safety and effectiveness. Methods:According to the properties of the active ingredients of each Chinese herb, herbs were extracted using decoction method and ethanol reflux extraction. The optimized extraction condi-tions were determined by orthogonal test,with the extracted amount,the amount of ethanol soluble matter and the amount of the n-butanol soluble matter as the index. Results:Xiakucao(Prunella),Wang Bu Liu Xing (Vaccaria),Zhe Bei Mu (Fritillaria),Shan Cigu (indica),and Chaihu (bupleurum) were extracted with 70%ethanol reflux extraction for 2 time 3 hr per for each time,with 10 folds and 8 folds amount of solvent added,respectively. After extracted for volatile oil,Ezhu (Curcuma),Baizhu (Atractylodes),Xiangfu (Cyperus) were mixed with mu li(Concha Ostreae),Kunbu(Thallus Laminariae) and water for 1 hr,and then decocted for 2 times,2 hr per time,with 8 folds and 6 folds amount of water,respectively. Conclusion:The extraction technology could extract the active ingredients effectively,which can ensure the effectiveness and safety of the preparation.关键词
夏王散结胶囊/乳腺增生症/提取工艺/正交试验Key words
Xiawang Sanjie capsule/hyperplasia of mammary glands/extraction technology/orthogonal test分类
医药卫生引用本文复制引用
魏冉,徐莉,林桂涛..夏王散结胶囊提取工艺研究[J].山东中医杂志,2017,36(3):237-240,4.基金项目
国家科技重大专项重大新药创制(编号:2009ZX09301-013) （编号:2009ZX09301-013）
