山东医药2017，Vol.57Issue(6)：24-26,3.DOI:10.3969/j.issn.1002-266X.2017.06.007
中国南方汉族人群特发性扩张型心肌病与 ACE 基因多态性的关系
Relationship between ACE gene polymorphism and idiopathic dilated cardiomyopathy in patients of south China
摘要
Abstract
Objective To explore the relationship between angiotensin-converting enzyme ( ACE ) rs4646994 gene polymorphism and idiopathic dilated cardiomyopathy ( IDC) in patients of south China .Methods We collected 64 IDC pa-tients in south China as the IDC group and 120 healthy persons as the control group , then investigated the ACE rs4646994 genotype in the fasting peripheral venous blood collected from the two groups by RT -PCR and detected the ACE concentra-tion in the plasma by UV spectrophotometer .Results In the IDC group, the frequency of DD genotype was 28.13%, which was significantly higher than that of the control group (10.00%) and the frequency of D allele was 50.79%, which was significantly higher than that of the control group (33.75%) (all P<0.05), but there was no significant difference in ID genotype, II genotype and I allele (all P>0.05).In the IDC group and control group , the ACE concentration in pa-tients with DD genotype was significantly higher than that of patients with ID genotype and II genotype ( P<0.05 or P<0.01), but no significant difference was found in the ACE concentration among the people with the same genotypes (all P>0.05).Conclusion The insertion/deletion polymorphism of ACE gene is associated with IDC , and the DD genotype and D allele of ACE gene may probably increase south China Han population at risk of IDC .关键词
血管紧张素转换酶/特发性扩张型心肌病/基因多态性/中国南方/汉族Key words
angiotensin-converting enzyme/idiopathic dilated cardiomyopathy/gene polymorphism/south China/Han nationality分类
医药卫生引用本文复制引用
陈雯,赵铁,陈代娣,刘奕莉,熊蒙,桂庆军..中国南方汉族人群特发性扩张型心肌病与 ACE 基因多态性的关系[J].山东医药,2017,57(6):24-26,3.基金项目
湖南省自然科学基金资助项目（2016JJ2109）；湖南省大学生研究性学习和创新性实验计划项目（湘教通2015-269-248号）。 （）
