中国组织工程研究2017，Vol.21Issue(6)：917-922,6.DOI:10.3969/j.issn.2095-4344.2017.06.017
聚乳酸-羟基乙酸导管移植修复坐骨神经损伤后的力学特性分析
Mechanical properties of sciatic nerve injury after repaired with poly(lactic acid-glycolic acid) scaffold
摘要
Abstract
BACKGROUND:The tensile and stress-relaxation mechanical properties of sciatic nerve injury after repaired with autologous nerve and poly(lactic acid-glycolic acid) (PLGA) scaffold are rarely reported. OBJECTIVE:To analyze the tensile and stress relaxation characteristics of sciatic nerve injury after the transplantation of autologous nerve and PLGA scaffold. METHODS:Sixty sciatic nerves were extracted from the fresh cadavers dead within 24 hours, processed into 35 mm samples, and were then randomly divided into three groups. The nerve samples in control group received no intervention;the nerves in artificial and autologous groups were modeled into 20 mm defects, followed by repaired with PLGA scaffold and autologous nerve, respectively. Afterwards, the tension and stress-relaxation tests were performed in each group. RESULTS AND CONCLUSION:The stress in each group descended fast at the first 600 seconds, then descended slowly and was closed to the horizontal level until 7200 seconds, and the stress-relaxation curves in each group were in logarithmic decrease. The order of the elastic limit load, elastic limit stress, maximum load, maximum stress, elastic limit strain and maximum strain during tension was as follows:control group>artificial group>autologous group (P<0.05). Our results indicate that the PLGA scaffold holds good tension and stress-relaxation properties, which meets the mechanical requirements of the biomaterials used for sciatic nerve repair.关键词
生物材料/材料相容性/聚乳酸-羟基乙酸/神经再生/周围神经损伤/坐骨神经损伤模型/自体神经/移植/修复/应力松弛分类
医药卫生引用本文复制引用
李正伟,吕雪漫,李新颖,李亚军,罗民..聚乳酸-羟基乙酸导管移植修复坐骨神经损伤后的力学特性分析[J].中国组织工程研究,2017,21(6):917-922,6.基金项目
吉林省科技发展基金项目(20116492):射频调控颈部神经治疗脑源性供血不足的临床研究基金资助:聚乳酸-羟基乙酸:Polyglyeolie lactieaeid,PLGA the Science and Technology Development Foundation of Jilin Province, No. 20116492 （20116492）
