中国病理生理杂志2017，Vol.33Issue(2)：349-352,4.DOI:10.3969/j.issn.1000-4718.2017.02.025
Mnk2和eIF4E在食管鳞状细胞癌中的表达及其临床意义
Expression and significance of Mnk2 and eIF4E in esophageal squamous cell carcinoma
摘要
Abstract
AIM: To investigate the expression and significance of MAPK-interacting kinase-2 ( Mnk2 ) and eukaryotic initiation factor 4E ( eIF4E) in the patients with resected esophageal squamous cell carcinoma ( ESCC ). METHODS:The protein expression of Mnk2 and eIF4E in ESCC tissues (98 cases) and normal esophageal tissues (20 cases) were assessed by immunohistochemistry (IHC), and their correlations with clinicopathological features were statisti-cally analyzed.RESULTS:The over-expression rate of Mnk2 and eIF4E was 68.4%(67/98) and 61.2%(60/98), re-spectively.The expression of Mnk2 had a positive correlation with eIF4E (P<0.05).Clinicopathologic analysis showed that Mnk2 expression was significantly correlated with T classification ( P<0.05 ) and clinical stage ( P<0.05 ) .CON-CLUSION:The over-expression of Mnk2 was significantly related to the tumor invasive depth , TNM stages and expression of eIF4E in ESCC.Expression of Mnk2 and eIF4E may have a cooperative formation mechanism in the development of ESCC.关键词
食管鳞状细胞癌/MAPK相互作用激酶-2/真核细胞翻译起始因子4EKey words
Esophageal squamous cell carcinoma/MAPK-interacting kinase-2/Eukaryotic initiation factor 4E分类
医药卫生引用本文复制引用
曾博,陈振光,罗红鹤,雷艺炎,冯沿芬,黄启涛,陈景福,张昕,韩向前,张水深,邹健勇,苏春华..Mnk2和eIF4E在食管鳞状细胞癌中的表达及其临床意义[J].中国病理生理杂志,2017,33(2):349-352,4.基金项目
广东省医学科研基金资助项目 （）
