中国肺癌杂志2017，Vol.20Issue(2)：88-92,5.DOI:10.3779/j.issn.1009-3419.2017.02.03
外科治疗Ⅲa期小细胞肺癌的疗效分析
Analysis of Efficacy of Surgical Treatment for Ⅲa Small Cell Lung Cancer
窦学军 1王志远 1王亮 1路伟强 1马云雷 1许绍发2
作者信息
- 1. 100049北京,航天中心医院
- 2. 101149北京,北京市胸科医院胸心外科
- 折叠
摘要
Abstract
Background and objective Small cell lung cancer (SCLC) accounts for nearly 15% of all cases of can-cer. As a type of highly invasive tumors, SCLC has high degree of malignancy, early and extensive metastasis, and is sensitive to chemotherapy and radiotherapy. The early treatment response rate of SCLC is high but it can also relapse rapidly without any treatment. Its median survival time is merely four to six months. Although many studies on SCLC have been conducted in re-cent years, its clinical treatment strategies have remained unchanged. The treatment of SCLC is still confined to chemotherapy regimens of etoposide plus cisplatin (EP) and other classic treatments because the surgical treatment of SCLC, particularly for Ⅲa treatment, has yet to reach a consensus. This study investigated the prognostic factors and clinical therapy effect in the comprehensive treatment of Ⅲa SCLC after surgical treatment.Methods This study was conducted through the retrospective analysis of the clinical data of 78 patients with SCLC who underwent surgical treatment in Beijing Chest Hospital affiliated to Capital Medical University between January 1995 and December 1995. Through follow-up, we performed statistical analysis of each patient's gender, age, tumor size, lymph node metastasis, tumor-node-metastasis (TNM) staging, surgical methods, and adjuvant radiation and chemotherapy.Results The median survival in this clinical trial team was 13.93 months. Among the participants, 47 patients accepted neoadjuvant chemotherapy and their median survival were 14.25 months. By contrast, 31 patients accepted postoperative adjuvant chemotherapy and their median survival were 13.83 months. No statistical difference was observed between the two groups. Moreover, 28 patients were of single Lymph node metastasis and their median survival was 17.1 months. By contrast, 50 patients were of multiple lymph node metastasis and their median survival was 11.9 months. Significant statistical difference was observed between the two groups (P<0.01).Conclusion In performing further evalua-tion of the status and value of surgical treatment in the comprehensive treatment of SCLC, several patients benefitted from Ⅲa SCLC surgery with comprehensive treatment.关键词
肺肿瘤/手术治疗/综合治疗/预后Key words
Lung neoplasms/Surgical treatment/Comprehensive treatment/Prognosis引用本文复制引用
窦学军,王志远,王亮,路伟强,马云雷,许绍发..外科治疗Ⅲa期小细胞肺癌的疗效分析[J].中国肺癌杂志,2017,20(2):88-92,5.
