中国肺癌杂志2017，Vol.20Issue(2)：100-106,7.DOI:10.3779/j.issn.1009-3419.2017.02.04
Ⅲa期非小细胞肺癌新辅助化疗的疗效分析及应用价值
Efficacy and Potential Application of Neoadjuvant Chemotherapy in Patients with Ⅲa Stage Non-small Cell Lung Cancer
摘要
Abstract
Background and objective The therapeutic effect and side effect of neoadjuvant chemotherapy were still disputing issues when applied to resectable Ⅲa stage non-small cell lung cancer (NSCLC) patients. The retrospective analysis was aimed to investigate the short-term efficacy and postoperative complications in resectable Ⅲa NSCLC patients treated with neoadjuvant chemotherapy.Methods According to inclusion criteria and exclusion criteria, 370 patients with clinical diagnosis of ⅢaNSCLC were selected from our hospital between January 2011 and October 2013 were retrospectively analyzed. According to treatment method, group A (preoperative neoadjuvant chemotherapy+surgery group) contained 97 cases, and 273 patients were included in group B (direct surgery without neoadjuvant treatment group). The clinical data, surgi-cal approach, main postoperative complications and disease-free survival (DFS) among patients in two groups were recorded. Results The total down-staging in group A was 65.98% (64/97), the R0 resection in group A and group B were 96.91% (94/97) and 90.48% (247/273), respectively. The operation time, bleeding, postoperative hospitalization were no statistical difference (P>0.05), and the main postoperative complications of the patients in two groups were 76.29% (74/97) and 72.52% (198/273) (P>0.05). All patients followed-up for 2 months-36 months, the median follow-up time was 12.7 months, the total recurrence and metastasis rates were 63.92% (62/97) and 94.87% (259/273) (P<0.05) and the median DFS were 19.46 months and 11.34 months (P<0.001).Conclusion Neoadjuvant chemotherapy can benefit patients of Ⅲa stage NSCLC partly in down-staging T and N stage in tumor, enhance the R0 resection, but not significantly increased the postoperative complications of the patients, which can reduce the local recurrence and metastasis, enhance the DFS effectively.关键词
肺肿瘤/新辅助化疗/无病生存期/疗效分析Key words
Lung neoplasms/Neoadjuvant chemotherapy/Disease-free survival/Efficacy引用本文复制引用
唐翠萍,秦思,伍万春,吴阳,张涛..Ⅲa期非小细胞肺癌新辅助化疗的疗效分析及应用价值[J].中国肺癌杂志,2017,20(2):100-106,7.基金项目
本研究受国家临床重点专科建设项目[国卫办医函(2013)544号]与重庆市自然科学基金资助项目(No.cstc2012jjA10138)资助 This study was supported by Oncology of National Clinical Specialist Project (No.[2013]544) and the grant from Natu-ral Science Foundation of Chongqing (to Tao ZHANG)(No.cstc2012jjA10138). （2013）
